Risk of serotonin symdrome w/ irreversible nonselective MAOIs. Reversible & selective MAO-A inhibitor eg, moclobemide. Reversible & nonselective MAOI eg, linezolid. Irreversible, selective MAO-B inihibitor eg, selegiline, rasagiline. Serotonergic drugs eg, tramadol, sumatriptan, other triptans. Higher AR incidence w/ St. John's wort-containing herbal remedies. Drugs lowering seizure threshold eg, antidepressants (tricyclics, SSRIs, SNRIs), neuroleptics (phenothazines, thioxanthenes, butyrophenones), mefloquin, bupropion, tramadol. Decreased AUC w/ rifampicin. Increased risk of bleeding w/ oral anticoagulants or antiplatelets. Enhanced effects w/ lithium or tryptophan.