Brintellix

Brintellix

vortioxetine

Manufacturer:

Lundbeck

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Vortioxetine
Indications/Uses
Major depressive episodes in adults.
Dosage/Direction for Use
Adult <65 yr Initially 10 mg once daily, may be increased to max 20 mg once daily or decreased to min 5 mg once daily. Elderly ≥65 yr Initially 5 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant use w/ nonselective MAOIs or selective MAO-A inhibitors.
Special Precautions
Discontinue use if seizures or increased seizure frequency, signs & symptoms of serotonin syndrome or neuroleptic malignant syndrome, symptomatic hyponatraemia occur; in patients entering manic phase. Monitor suicidal behaviour, thoughts or clinical worsening. History of suicide-related events or exhibiting significant degree of suicidal ideation; seizures or unstable epilepsy; mania/hypomania; known bleeding tendencies/disorders. Concomitant use w/ anticoagulants &/or drugs affecting platelet function eg, atypical antipsychotics & phenothiazines, most TCAs, NSAIDs, acetylsalicylic acid; drugs causing hyponatraemia. May affect ability to drive & use machines. Liver cirrhosis. Severe renal & hepatic impairment. Pregnancy & lactation. Not recommended in childn & adolescents <18 yr. Elderly ≥65 yr.
Adverse Reactions
Nausea. Abnormal dreams; dizziness; diarrhoea, constipation, vomiting; generalised pruritus.
Drug Interactions
Risk of serotonin symdrome w/ irreversible nonselective MAOIs. Reversible & selective MAO-A inhibitor eg, moclobemide. Reversible & nonselective MAOI eg, linezolid. Irreversible, selective MAO-B inihibitor eg, selegiline, rasagiline. Serotonergic drugs eg, tramadol, sumatriptan, other triptans. Higher AR incidence w/ St. John's wort-containing herbal remedies. Drugs lowering seizure threshold eg, antidepressants (tricyclics, SSRIs, SNRIs), neuroleptics (phenothazines, thioxanthenes, butyrophenones), mefloquin, bupropion, tramadol. Decreased AUC w/ rifampicin. Increased risk of bleeding w/ oral anticoagulants or antiplatelets. Enhanced effects w/ lithium or tryptophan.
MIMS Class
ATC Classification
N06AX26 - vortioxetine ; Belongs to the class of other antidepressants.
Presentation/Packing
Form
Brintellix FC tab 10 mg
Packing/Price
28's
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