Buflomedil


Concise Prescribing Info
Indications/Uses
Cerebrovascular and peripheral vascular disease.
Dosage/Direction for Use
Adult : PO 300-600 mg/day. IV Up to 200 mg/day via slow inj or up to 400 mg/day via infusion. IM Up to 100 mg/day.
Dosage Details
Intramuscular
Cerebrovascular and peripheral vascular disease
Adult: Up to 100 mg daily.

Intravenous
Cerebrovascular and peripheral vascular disease
Adult: Up to 200 mg daily by slow IV Inj or up to 400 mg daily by IV infusion.

Oral
Cerebrovascular and peripheral vascular disease
Adult: 300-600 mg daily.
Special Precautions
May affect ability to drive or operate machinery. Renal or hepatic impairment.
Adverse Reactions
GI disturbances, headache, vertigo, syncope, rash, pruritus, paraesthesia, cephalea, lightheadednesss, dizziness, itching, flushing.
Overdosage
Overdosage may lead to tachycardia, severe hypotension and convulsions.
Drug Interactions
Synergism with antihypertensives.
Action
Description: Buflomedil enhances RBC deformibility, muscle cell metabolism as well as platelet inhibition, thus bringing about vasodilating effects.
Pharmacokinetics:
Absorption: Absorbed from the GI tract; plasma concentrations peaked at 1.5-4 hr after oral admin.
Distribution: Widely distributed. Plasma proetin binding: Dose-dependent and ranges from 60-80%.
Metabolism: Metabolised hepatically.
Excretion: Elimination half-life: 2-3 hr. Mainly excreted in the urine as unchanged drug and metabolites.
Disclaimer: This information is independently developed by MIMS based on Buflomedil from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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