Generic Medicine Info
Indications and Dosage
Skin fungal infections
Adult: As 1% cream: Tinea pedis: Apply to affected skin between and around the toes bid for 7 days or once daily for 4 wk. Tinea corporis and tinea cruris: Apply to affected area once daily for 2 wk. Tinea versicolor: Apply to affected area and surrounding skin once daily for 1-2 wk.
Child: ≥12 yr Same as adult dose.
Hypersensitivity to butenafine.
Special Precautions
Patients w/ allylamine antifungal (e.g. terbinafine, naftifine) hypersensitivity. Not intended for the treatment of scalp or nail infections.
Adverse Reactions
Burning/stinging sensation, contact dermatitis, erythema, pruritus, skin irritation.
Patient Counseling Information
Avoid contact w/ eyes or other mucous membranes. Avoid occlusive dressings.
Monitoring Parameters
Perform direct microscopic examination of infected superficial epidermal tissue in potassium hydroxide (KOH) soln or culture examination using appropriate medium prior to initiation of treatment.
Description: Butenafine, a benzylamine antifungal, inhibits the enzyme squalene monooxygenase, thus decreasing sterol biosynthesis w/ subsequent weakening of fungal cell membranes.
Absorption: Minimal systemic absorption. Time to peak serum concentration: 6-15 hr.
Metabolism: Metabolised hepatically via hydroxylation.
Excretion: Elimination half-life: Biphasic: 35 hr; >150 hr.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Butenafine, CID=2484, https://pubchem.ncbi.nlm.nih.gov/compound/Butenafine (accessed on Jan. 22, 2020)

Store between 5-30°C.
MIMS Class
Topical Antifungals & Antiparasites
ATC Classification
D01AE23 - butenafine ; Belongs to the class of other antifungals for topical use.
Anon. Butenafine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/08/2016.

Buckingham R (ed). Butenafine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/08/2016.

Lotrimin Ultra Athletes Foot Cream (Bayer Healthcare LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 12/08/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Butenafine Hydrochloride (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 12/08/2016.

Mentax Cream (Mylan Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 12/08/2016.

Disclaimer: This information is independently developed by MIMS based on Butenafine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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