Cancidas Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Caspofungin acetate

Indications/Uses

In adult & ped patients ≥12 mth for invasive candidiasis including candidemia; esophageal candidiasis; invasive aspergillosis in patients who are refractory to or intolerant of other therapies (ie, amphotericin B, lipid formulations of amphotericin B &/or itraconazole). Empirical therapy for presumed fungal infections in febrile, neutropenic patients.

Click to view Cancidas detailed prescribing information

Dosage/Direction for Use

Administer by slow IV infusion over approx 1 hr. Adult Empirical therapy 70 mg single loading dose on Day 1, then 50 mg daily thereafter. Duration: Fungal infection Min of 14 days; continue for at least 7 days after both neutropenia & clinical symptoms are resolved. Invasive candidiasis 70 mg single loading dose on Day 1, then 50 mg daily thereafter. Continue for at least 14 days after last +ve culture. Esophageal candidiasis 50 mg daily. Invasive aspergillosis 70 mg single loading dose on Day 1, then 50 mg daily thereafter. Childn 12 mth-17 yr 70 mg/m² single loading dose on Day 1, then 50 mg/m² daily thereafter.

Click to view Cancidas detailed prescribing information

Overdosage

View Cancidas overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity.

Click to view Cancidas detailed prescribing information

Special Precautions

Discontinue use if anaphylaxis occurs. History of allergic skin reactions. Concomitant use w/ cyclosporin. Monitor LFTs & evidence of worsening hepatic function. Not to be used during pregnancy & lactation. Neonates & infants <3 mth.

Click to view Cancidas detailed prescribing information

Use In Pregnancy & Lactation

Click to view Cancidas detailed prescribing information

Adverse Reactions

Hypersensitivity reactions. Fever, headache, abdominal pain, pain, chills; nausea, diarrhea, vomiting; elevated liver enzyme levels; increased serum creatinine; anemia (decreased Hb & hematocrit); tachycardia; phlebitis/thrombophlebitis, infused-vein complication, flushing; dyspnea; rash, pruritus; catheter site pain, hypotension.

Drug Interactions

Increased AUC by cyclosporin. Reduced blood conc of tacrolimus. Transient elevated plasma conc w/ rifampin. Efavirenz, nevirapine, phenytoin, dexamethasone, carbamazepine.

Click to view Cancidas detailed prescribing information

Storage

View Cancidas storage conditions for details to ensure optimal shelf-life.

Description

View Cancidas description for details of the chemical structure and excipients (inactive components).

Action

View Cancidas mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Antifungals

ATC Classification

J02AX04 - caspofungin ; Belongs to the class of other systemic antimycotics.

Regulatory Classification

Presentation/Packing

Form

Cancidas inj (vial) 50 mg

Packing/Price

1's

Form

Cancidas inj (vial) 70 mg

Packing/Price

1's

Cancidas

caspofungin

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma