Carbetocin


Concise Prescribing Info
Indications/Uses
Prophylaxis of uterine atony and excessive bleeding after caesarean section.
Dosage/Direction for Use
Adult : IV 100 mcg as a single dose, given after delivery of infant.
Dosage Details
Intravenous
Prophylaxis of uterine atony and excessive bleeding after caesarean section
Adult: 100 mcg as a single dose via bolus inj slowly over 1 min, given after delivery of infant (preferably before removal of placenta).
Renal Impairment
Contraindicated.
Hepatic Impairment
Contraindicated.
Contraindications
Pre-eclampsia/eclampsia, severe CV disease, epilepsy. Admin prior to delivery, including induction of labour (elective or medical). Hepatic and renal impairment. Pregnancy.
Special Precautions
Patient w/ asthma, migraine, CV disease, hyponatraemia. Lactation.
Adverse Reactions
Headache, dizziness, tremor, anxiety; tachycardia, hypotension, flushing, sweating; dyspnoea, pruritus; chest and back pain, chills, feeling of warmth; nausea, vomiting, abdominal pain, metallic taste; anaemia.
MonitoringParameters
Monitor for persistent postpartum bleeding and BP.
Overdosage
Symptoms: Uterine hyperactivity and rupture, postpartum haemorrhage, hyponatraemia, water intoxication. Management: Symptomatic and supportive treatment. Provide oxygen to the patient. Restrict fluid intake, promote diuresis, correct electrolyte imbalance, and control convulsion in case of water intoxication.
Drug Interactions
Potentiated effect w/ prostaglandins. Enhanced hypotensive effect w/ inhalational anaesthetics (e.g. halothane). May cause severe HTN w/ vasoconstrictors in conjunction w/ caudal-block anaesthesia. May enhance BP w/ ergot alkaloids (e.g. methylergometrine).
Action
Description: Carbetocin is a synthetic analogue of oxytocin w/ a longer duration of action. It selectively binds to oxytocin receptors in the uterine smooth muscle, stimulating rhythmic uterine contractions and increasing both the frequency of existing contractions and uterine tone. Additionally, it enhances uterine involution early in postpartum.
Onset: W/in 2 min.
Duration: Approx 1 hr.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: W/in 1 hr.
Distribution: Enters breast milk (small amount).
Excretion: Via urine (<1% as unchanged drug). Terminal elimination half-life: Approx 40 min.
Chemical Structure

Chemical Structure Image
Carbetocin

Source: National Center for Biotechnology Information. PubChem Database. Carbetocin, CID=16681432, https://pubchem.ncbi.nlm.nih.gov/compound/Carbetocin (accessed on Jan. 21, 2020)

Storage
Store between 2-8°C. Do not freeze.
ATC Classification
H01BB03 - carbetocin ; Belongs to the class of oxytocin and analogues. Used in posterior pituitary lobe hormone preparations.
References
Anon. Carbetocin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 11/11/2016.

Buckingham R (ed). Carbetocin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/11/2016.

Joint Formulary Committee. Carbetocin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/11/2016.

Disclaimer: This information is independently developed by MIMS based on Carbetocin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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