Carboplatin Pfizer

Carboplatin Pfizer

carboplatin

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Carboplatin
Indications/Uses
Advanced ovarian carcinoma of epithelial origin.
Dosage/Direction for Use
400 mg/m2 as single IV infusion over 15-60 min. Repeat dose until 4 wk later. CrCl >40 mL/min 400 mg/m2, 20-39 mL/min 250 mg/m2, 0-19 mL/min 150 mg/m2.
Contraindications
Hypersensitivity to carboplatin or platinum-containing compd. Preexisting severe renal impairment. Severe myelosuppression & bleeding. Pregnancy & lactation.
Special Precautions
Hypersensitivity. Myelosuppression. Ototoxicity. Severe or refractory emetogenic effects. Monitor peripheral blood counts prior to, during & after treatment. Perform neurological evaluations & auditory monitoring regularly. Concomitant nephrotoxic drugs, previous chemotherapy. Avoid use w/ live vaccines. Renal impairment. Women of childbearing potential should use adequate contraception. Not recommended during pregnancy. Not to be used during lactation.
Adverse Reactions
Hematological toxicity, leucopenia, thrombocytopenia, anemia, neutropenia; nausea, vomiting, diarrhea, constipation; transient serum alkaline phosphatase, aspartate aminotransferase or bilirubin conc elevations; tinnitus, hearing loss; visual abnormalities; cardiac failure, ischemic coronary artery disorders; cerebrovascular events; hypersensitivity reactions; erythematous rash, pruritus, urticaria, alopecia; myalgia/arthralgia; neurotoxicity; electrolyte abnormalities.
Drug Interactions
Avoid cumulative toxic effect w/ other myelosuppressive agents by warranting dosage adjustments. Possible renal impairment w/ aminoglycosides or other nephrotoxic drugs. Black precipitate w/ Al.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01XA02 - carboplatin ; Belongs to the class of platinum-containing antineoplastic agents. Used in the treatment of cancer.
Presentation/Packing
Form
Carboplatin Pfizer inj (vial) 10 mg/mL
Packing/Price
15 mL x 1's;45 mL x 1's;5 mL x 1's
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