Cefazolin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV/IM Susceptible infections Mild: 0.25-0.5 g 8 hrly. Moderate to severe: 0.5-1 g 6-8 hrly. Severe, life-threatening: 1-1.5 g 6 hrly. Max: 12 g/day. Acute uncomplicated UTI 1 g 12 hrly. Max: 12 g/day. Pneumonia 500 mg 12 hrly. Max: 12 g/day. Prophylaxis of surgical infections 1 g given 30-60 min prior to surgery, followed by 0.5-1 g during surgery for lengthy procedures, then 0.5-1 g 6-8 hrly after surgery for 24 hr or up to 5 days. All doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion.
Dosage Details
Parenteral
Susceptible infections
Adult: Mild: 0.25-0.5 g 8 hrly. Moderate to severe: 0.5-1 g 6-8 hrly. Severe, life-threatening: 1-1.5 g 6 hrly. Max: 12 g daily. All doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion.
Child: >1 yr 25-50 mg/kg daily in 3 or 4 divided doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 100 mg/kg daily in divided doses for severe infections.

Parenteral
Acute uncomplicated urinary tract infections
Adult: 1 g 12 hrly to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 12 g daily.
Child: >1 yr 25-50 mg/kg daily in 3 or 4 divided doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 100 mg/kg daily in divided doses for severe infections.

Parenteral
Pneumonia
Adult: 500 mg 12 hrly to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 12 g daily.
Child: >1 yr 25-50 mg/kg daily in 3 or 4 divided doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 100 mg/kg daily in divided doses for severe infections.

Parenteral
Prophylaxis of surgical infections
Adult: 1 g given 30-60 min prior to surgery, followed by 0.5-1 g during surgery for lengthy procedures, then 0.5-1 g 6-8 hrly after surgery for 24 hr or up to 5 days. All doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion.
Renal Impairment
CrCl Dosage
≤10 Half the usual dose 18-24 hrly.
11-34 Half the usual dose 12 hrly.
35-54 Usual dose at intervals of at least 8 hr.
Reconstitution
Add 2 or 2.5 mL of sterile water for inj to the vial labelled as 500 mg or 1 g, respectively, to provide soln containing approx 225 or 330 mg/mL. Further dilute in approx 5 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV soln for IV infusion.
Incompatibility
Aminoglycosides. Y-site: Amphotericin B cholesteryl sulfate complex, caspofungin, idarubicin, pemetrexed, pentamidine, vinorelbine. Variable: Amiodarone, anakinra, cisatracurium, doxapram, hetastarch in NS, hydromorphone, pantoprazole, promethazine, vancomycin.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Patient w/ history of hypersensitivity to penicillins, GI disease particularly colitis, seizure disorder. Renal impairment. Pregnancy and lactation.
Adverse Reactions
Diarrhoea, oral candidiasis, vomiting, nausea, stomach cramps, anorexia; eosinophilia, itching, drug fever, skin rash, Stevens-Johnson syndrome; neutropenia, leucopenia, thrombocytopenia, thrombocythemia; transient elevation in SGOT, SGPT and alkaline phosphatase levels; hepatitis; increased BUN and creatinine levels, renal failure; phlebitis, induration; genital and anal pruritus (e.g. vulvar pruritus, genital moniliasis, vaginitis).
Potentially Fatal: Anaphylaxis, pseudomembranous colitis.
IM/Intraocular/Intraperitoneal/IV/Parenteral: B
MonitoringParameters
Monitor prothrombin time; renal, hepatic and haematological function; monitor for signs of anaphylaxis during 1st dose.
Drug Interactions
May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin). May diminish the therapeutic effect of Na picosulfate, BCG and typhoid vaccine. May decrease the protein binding of fosphenytoin and phenytoin. Probenecid may decrease renal tubular secretion of cefazolin, resulting in increased and prolonged blood levels. May increase the nephrotoxic effects of aminoglycosides.
Food Interaction
Disulfiram-like reaction w/ alcohol.
Lab Interference
False-positive reaction in urinary glucose test using Benedict's soln, Fehling's soln or Clinitest tablets. Positive direct and indirect Coombs test.
Action
Description: Cefazolin binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Pharmacokinetics:
Absorption: Poorly absorbed from GI tract. Time to peak plasma concentration: 1 hr (IM).
Distribution: Diffuses into bone, ascitic, pleural and synovial fluids; CSF (small amount). Crosses the placenta and enters breast milk. Plasma protein-binding: Approx 85%.
Metabolism: Minimally hepatic.
Excretion: Via urine (80-100% as unchanged drug). Plasma half-life: Approx 1.8 hr.
Chemical Structure

Click on icon to see table/diagram/image
Storage
Store between 20-25°C. Protect from light. Reconstituted soln/premixed inj: Store at or below -20°C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Cefazolin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Cefazolin Sandoz
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