Cefobid

Cefobid

cefoperazone

Manufacturer:

Pfizer

Distributor:

DKSH

Marketer:

DKSH
Concise Prescribing Info
Contents
Cefoperazone Na
Indications/Uses
Upper & lower resp tract infections & UTI, peritonitis, cholecystitis, cholangitis & other intra-abdominal infections, septicemia, meningitis, skin & soft tissue infections, bones & joints infections, pelvic inflammatory disease, endometritis, gonorrhoea & other genital tract infections. Prophylaxis of post-op infection in patients undergoing abdominal & gynaecological surgery, CV & orthopedic surgery.
Dosage/Direction for Use
Adult 2-4 g daily in equally divided doses every 12 hr. Severe infections May be increased to 8 g daily in equally divided doses every 12 hr. Uncomplicated gonococcal urethritis 500 mg IM as single dose. Childn & infant 50-200 mg/kg daily in 2 divided doses every 8-12 hr. Max: Not to exceed 12 g daily. Neonate <8 days 50-200 mg/kg daily every 12 hr. IV administration in adult & childn 1-2 g over 15 min-1 hr. Max dose for adult: 2 g/administration. Max dose for childn: 50 mg/kg/administration. Antibiotic prophylaxis of surgical procedures 1-2 g IV 30-90 min pre-op. Renal dysfunction Max dose: 4 g daily. Hepatic dysfunction & concurrent renal dysfunction Not to exceed 2 g daily.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Hypersensitivity. Penicillin-sensitive patients. Monitor prothrombin time in patients w/ poor diet, malabsorption states & on prolonged IV alimentation regimens. Prolonged use may cause overgrowth of nonsusceptible organisms. Clostridium difficile-associated diarrhea. Severe biliary obstruction. Severe hepatic disease or coexistent renal dysfunction. Pregnancy & lactation. Premature infants & neonates.
Adverse Reactions
Decreased Hb, hematocrit. Neutropenia, +ve Coombs' direct test, thrombocytopenia, eosinophilia; infusion site phlebitis; diarrhea; increased aspartate & alanine aminotransferase & blood alkaline phosphatase, jaundice; pruritus, urticaria, maculopapular rash.
Drug Interactions
Disulfiram-like reaction w/ alcohol. Avoid use of ethanol-containing soln. False +ve urine glucose reaction.
MIMS Class
ATC Classification
J01DD12 - cefoperazone ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cefobid powd for inj 2 g
Packing/Price
1's
Form
Cefobid powd for inj 1 g
Packing/Price
1's
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