Adult 2-4 g daily in equally divided doses every 12 hr. Severe infections May be increased to 8 g daily in equally divided doses every 12 hr. Uncomplicated gonococcal urethritis 500 mg IM as single dose. Childn & infant 50-200 mg/kg daily in 2 divided doses every 8-12 hr. Max: Not to exceed 12 g daily. Neonate <8 days 50-200 mg/kg daily every 12 hr. IV administration in adult & childn 1-2 g over 15 min-1 hr. Max dose for adult: 2 g/administration. Max dose for childn: 50 mg/kg/administration. Antibiotic prophylaxis of surgical procedures 1-2 g IV 30-90 min pre-op. Renal dysfunction Max dose: 4 g daily. Hepatic dysfunction & concurrent renal dysfunction Not to exceed 2 g daily.
Hypersensitivity. Penicillin-sensitive patients. Monitor prothrombin time in patients w/ poor diet, malabsorption states & on prolonged IV alimentation regimens. Prolonged use may cause overgrowth of nonsusceptible organisms. Clostridium difficile-associated diarrhea. Severe biliary obstruction. Severe hepatic disease or coexistent renal dysfunction. Pregnancy & lactation. Premature infants & neonates.
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