Usage During Pregnancy: Reproduction studies have been performed in mice, rats and monkeys at doses up to 10 times the human dose and have revealed no evidence of impaired fertility and did not show any teratological findings. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Usage in Nursing Mothers: Only small quantities of cefoperazone are excreted in human milk. Although cefoperazone passes poorly into breast milk of nursing mothers, caution should be exercised when cefoperazone is administered to a nursing mother.