Cefpar SB

Cefpar SB

cefoperazone + sulbactam

Manufacturer:

KAPL

Distributor:

Averroes Pharma
Concise Prescribing Info
Contents
Cefoperazone Na 500 mg, sulbactam Na 500 mg
Indications/Uses
Upper & lower resp tract infections & UTI; peritonitis, cholecystitis, cholangitis & other intra-abdominal infections; septicemia; meningitis; skin & soft tissue infections; bone & joint infections; pelvic inflammatory disease, endometritis, gonorrhea & other genital tract infections.
Dosage/Direction for Use
IV/IM Adult 2-4 g in equally divided doses every 12 hr. Severe or refractory infections May be increased up to 8 g in equally divided doses every 12 hr. Max dose: Sulbactam 4 g daily. Childn 40-80 mg/kg daily in equally divided doses every 6-12 hr. Serious or refractory infections May be increased up to 160 mg/kg daily in 2-4 equally divided doses. Neonate up to 1 wk Max dose: Not to exceed sulbactam 80 mg/kg daily every 12 hr. CrCl 15-30 mL/min Max: Sulbactam 1 g every 12 hr, <15 mL/min Max: Sulbactam 500 mg every 12 hr.
Contraindications
Hypersensitivity to penicillins, sulbactam, cefoperazone or cephalosporins.
Special Precautions
Discontinue use if allergic reaction occurs. Risk of vit K deficiency eg, patients w/ poor diet, malabsorption states (cystic fibrosis) & on prolonged IV alimentation regimens. Overgrowth of nonsusceptible organism due to prolonged use. Monitor prothrombin time in patients receiving anticoagulant therapy & exogenous vit K. Periodically check organ system dysfunction in extended therapy. Severe biliary obstruction &/or hepatic disease or coexistent renal dysfunction. Pregnancy & lactation. Premature infants & neonates.
Adverse Reactions
Diarrhea/loose stools, nausea & vomiting; maculopapular rash, urticaria; reversible neutropenia, decreased Hb or hematocrit, transient eosinophilia, thrombocytopenia, hypoprothrombinemia; headache, fever, inj pain, chills; transient SGOT, SGPT, alkaline phosphatase & bilirubin elevations. Anaphylactoid reaction (eg, shock); hypotension; Pseudomembranous colitis; leucopenia; pruritus, Stevens-Johnson syndrome; hematuria; vasculitis.
Drug Interactions
Avoid use of alcohol- & ethanol-containing soln. False +ve urine glucose reaction.
MIMS Class
ATC Classification
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cefpar SB powd for inj 1 g
Packing/Price
10 × 1's;1's
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