cefoperazone + sulbactam




Concise Prescribing Info
Sulbactam Na equiv to sulbactam 500 mg, cefoperazone Na equiv to cefoperazone 500 mg
Upper & lower resp tract infection; upper & lower UTI; peritonitis, cholecystitis, cholangitis, septicemia, meningitis, pelvic inflammatory disease, endometritis, gonorrhea; genital tract, skin & soft tissue, bone & joint infections.
Dosage/Direction for Use
IM/IV Usual dose: Adult 2-4 g daily in equally divided doses every 12 hr. Severe infections May be increased up to 8 g daily. Childn 40-80 mg/kg daily in equally divided doses every 6-12 hr. Severe or refractory infections May be increased up to 160 mg/kg daily. Max dose of sulbactam: 4 g daily.
Hypersensitivity to penicillins, cephalosporins, cefoperazone & sulbactam.
Special Precautions
Vit K deficiency w/ cefoperazone in patients w/ poor diet, malabsorption states eg, cystic fibrosis, prolonged IV alimentation regimen, receiving anticoagulant. Monitor prothrombin time. Periodically check organ system dysfunction in extended therapy. Hepatic & renal dysfunction. Pregnancy & lactation.
Adverse Reactions
Nausea, vomiting, loose stool, Pseudomembranous colitis; maculopapular rash, urticaria; hypotension; neutropenia, decreased Hb or hematocrit; transient eosinophilia, thrombocytopenia, hypoprothrombinemia; headache, fever, inj pain, chills; transient elevations of liver function test, SGOT, SGPT, alkaline phosphatase, bilirubin; transient pain, phlebitis.
MIMS Class
ATC Classification
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Cefper powd for inj
1 g x 1's
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