Cerazette

Cerazette

desogestrel

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma

Marketer:

A. Menarini
Concise Prescribing Info
Contents
Desogestrel
Dosage/Direction for Use
Administration
May be taken with or without food: Take at the same time each day.
Contraindications
Hypersensitivity. Active venous thromboembolic disorder; known or suspected sex steroid-sensitive malignancies; undiagnosed vag bleeding. Presence or history of severe hepatic disease. Known or suspected pregnancy.
Special Precautions
Discontinue use if thrombosis & sustained HTN develops; in case of long-term immobilisation due to surgery or illness. Not for protection against HIV & other STDs. Breast & liver cancer; history of thromboembolic disorders; history of chloasma gravidarum; jaundice &/or pruritus related to cholestasis, gallstone formation, porphyria, SLE, haemolytic uraemic syndrome, Syndenham's chorea, herpes gestationis, ostosclerosis-related hearing loss, hereditary angioedema; GI disturbances. Diabetic patients especially during 1st mth of therapy. Changes in vag bleeding pattern; follicular development. Monitor estradiol serum levels. Concomitant use w/ medications decreasing etonogestrel plasma conc. Avoid sun or UV radiation exposure. Not to be used in patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Ectopic pregnancy. Not to be used during pregnancy. Growth & development of breastfed infants.
Adverse Reactions
Altered mood, decreased libido; headache; nausea; acne; breast pain, irregular menstruation, amenorrhoea; increased wt.
Drug Interactions
Decreased efficacy w/ phenytoin, phenobarb, primidone, bosentan, carbamazepine, rifampicin, oxcarbazepine, rifabutin, topiramate, felbamate, griseofulvin, ritonavir, nelfinavir, efavirenz, St. John's wort. Increased or decreased plasma conc w/ HIV PIs (eg, nelfinavir), NNRTIs (eg, nevirapine), HCV medicinal products (eg, boceprevir, telaprevir). Increased serum conc w/ strong (eg, ketoconazole, itraconazole, clarithromycin) or moderate (eg, fluconazole, diltiazem, erythromycin) CYP3A4 inhibitors. Reduced steroid absorption & efficacy w/ medical charcoal. Increased plasma & tissue conc of ciclosporin. Decreased plasma & tissue conc of lamotrigine.
MIMS Class
Oral Contraceptives
ATC Classification
G03AC09 - desogestrel ; Belongs to the class of progestogens. Used as systemic contraceptives.
Presentation/Packing
Form
Cerazette FC tab 75 mcg
Packing/Price
28's
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