Ciclosporin is used on its own or together with other medicines to prevent organ rejection in kidney, heart and liver transplants.
This medicine may also be used to treat chronic organ rejection and certain immune disorders of the joint, skin, and kidney.
This medicine may be used to treat other conditions as decided by your doctor.
Take Ciclosporin exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take it with or without food. Try to take it consistently with relation to meals and at the same time each day.
This medicine is available as a capsule or as an oral suspension.
If you are taking the modified-release type of capsule, swallow it whole. Do not break or chew the capsule.
If you are taking an oral suspension, use the measuring syringe provided to measure your dose. Remove the protective cover of the syringe, withdraw the prescribed dose from the bottle of the oral solution, and transfer it in a glass container. You may dilute the measured dose with milk, chocolate milk, orange juice, or apple juice at room temperature. Stir the diluted solution well and administer immediately.
There is a specific dosage recommendation for each formulation and brand of this medicine. Different preparation of this medicine cannot be substituted for each other. Ask your doctor or pharmacist before switching.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.
Ciclosporin must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to use your medicine, let your doctor and pharmacist know.
If you are using this medicine for other conditions, aside from treatment and prevention of organ rejection, alert your doctor if you have the following:
- kidney disease
- uncontrolled high blood pressure
- uncontrolled infection
as this medicine may not be suitable to you.
Do not take this Ciclosporin with medicine used to treat high blood pressure that affects the arteries (blood vessels) in your lungs (e.g. bosentan).
Inform your doctor if you have liver disease.
Let your doctor know if you are pregnant or breastfeeding.
This medicine may cause sensitivity to light. Apply sunscreen when going outdoors and avoid direct or prolonged exposure to sunlight and UV lamps.
Do not receive any vaccinations without first asking your doctor.
If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
Your blood pressure may rise to unsafe levels without you noticing it. Monitor blood pressure regularly.
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may also need to do routine blood tests (e.g. liver function tests, kidney function tests, complete blood count, and levels of calcium, magnesium, potassium, uric acid, lipid in the blood) while you are being treated with this medicine.
Ciclosporin may cause any of the following side effects: headache, nausea, diarrhoea, stomach pain or discomfort, tiredness, excessive hair growth, uncontrollable shaking of your body, leg cramps, numbness and abnormal tingling sensation, increased size of the gum, flushing and acne.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- yellowing of the skin or eyes
- swelling of the face, feet or hands
- abnormal decreased in frequency and amount of urine
- flu-like symptoms such as fever, chills, sore throat, joint pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Ciclosporin with medicine used to treat high blood pressure that affects the arteries (blood vessels) in your lungs (e.g. bosentan).
Inform your doctor and pharmacist if you are taking any of these medicines:
- antibiotics e.g. azithromycin, clarithromycin, erythromycin, gentamicin, tobramycin, ciprofloxacin
- medicines to treat fungal infection e.g. fluconazole, itraconazole, ketoconazole, amphotericin B, terbinafine
- medicines for high blood pressure or heart disease e.g. amiodarone, digoxin, nifedipine, diltiazem, verapamil
- water pill e.g. potassium sparing diuretic
- cholesterol-lowering medicines e.g. atorvastatin, lovastatin, simvastatin, fibric acid
- medicines for pain and inflammation e.g. diclofenac
- stomach medicines e.g. cimetidine, ranitidine
- medicines for epilepsy (fits or seizure) e.g. carbamazepine, phenytoin
- medicines used to treat cancer e.g. etoposide, melphalan, methotrexate
- medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
- other medicines used in organ transplant or certain immune disorders e.g. everolimus, sirolimus
- herbal supplement e.g. St. John’s wort
This list does not include all medicines that may interact with Ciclosporin.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
Avoid alcohol and grapefruit juice.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.