Prophylaxis of gastrointestinal haemorrhage from stress ulceration
Adult: In critically ill patients: 200-400 mg 4-6 hourly via the oral or nasogastric route.
Prophylaxis of acid aspiration during general anaesthesia
Adult: As tab: 400 mg given 90-120 minutes before induction of anaesthesia. In obstetric patients: 400 mg at the start of labour, may increase dose up to 400 mg 4 hourly if necessary. Max: 2,400 mg daily.
Gastro-oesophageal reflux disease
Adult: 400 mg 4 times daily or 800 mg bid for 4-12 weeks.
Hypersecretory conditions, Zollinger-Ellison syndrome
Adult: 300 or 400 mg 4 times daily, may increase dose if necessary. Max: 2,400 mg daily. Doses are individualised according to patient's needs.
Short bowel syndrome
Adult: Initially, 400 mg bid, adjust dose according to response.
Benign gastric and duodenal ulceration
Adult: 800 mg daily at bedtime or 400 mg bid for 4 weeks for duodenal ulcer, 6 weeks for gastric ulcer, and 8 weeks for NSAID-associated ulcer; may increase dose to 400 mg 4 times daily as necessary. Maintenance: 400 mg daily at bedtime or bid. Dosage recommendation may vary among countries or individual products. Refer to specific product guidelines.
Adult: 800-1,600 mg daily in 4 divided doses, 60-90 minutes before meals.