Cinoxacin


Concise Prescribing Info
Indications/Uses
UTI.
Dosage/Direction for Use
Adult : PO Treatment: 500 mg twice daily. Prophylaxis: 500 mg once nightly.
Dosage Details
Oral
Urinary tract infections
Adult: Treatment: 500 mg bid. Prophylaxis: 500 mg daily at bedtime as a single dose.
Renal Impairment
Avoid use or use in reduced dose.
Administration
May be taken with or without food. Take consistently w/ or w/o meals.
Contraindications
Hypersensitivity; severe renal impairment; pregnancy, lactation; babies <3 mth, child, adolescent; convulsive conditions.
Special Precautions
G6PD deficiency; impaired renal or hepatic function; exposure to strong sunlight; porphyria. Monitor blood counts, renal and hepatic function if treatment is >2 wk Arthralgia (discontinue).
Adverse Reactions
Hypersensitivity reactions; nausea, vomiting, diarrhoea; abdominal pain; neurological effects; toxic psychoses or convulsions; skin reactions; tendon damage; hepatic effects.
Potentially Fatal: Auto-immune haemolytic anaemia (elderly).
Drug Interactions
Probenecid, ciclosporin, oral anticoagulants, NSAIDS, xanthines; nitrofurantoin.
Potentially Fatal: High-dose IV melphalan in child.
Lab Interference
False-positive results in urinary glucose tests using copper reduction method.
Action
Description: Cinoxacin inhibits DNA gyrase activity thus interfering with bacterial DNA replication. It is active against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive bacteria and anaerobes are not susceptible.
Pharmacokinetics:
Absorption: Rapidly and almost completely absorbed after oral admin.
Distribution: >60% bound to plasma proteins.
Metabolism: Metabolised hepatically.
Excretion: Renally excreted; >95% of a dose is recovered in the urine within 24 hr.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Cinoxacin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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