Effects on the Gastrointestinal Tract:
Nausea, diarrhoea, vomiting, digestive disorders, abdominal pain, flatulence, anorexia. The doctor should be advised of any severe or persistent diarrhoea occurring during or after treatment, since these symptoms could conceal a serious intestinal disorder (pseudomembranous colitis) requiring urgent treatment. In such cases, Cipquin should be discontinued and replaced by another appropriate drug. Preparations which inhibit peristalsis are contraindicated.
Effects on the Nervous Systems:
Dizziness, headache, insomnia, agitation, trembling. Very Rarely: Peripheral paralgesia, sweating, unsteady gait, convulsions, anxiety states, nightmares, confusion, depressions, hallucinations. In some instances, these reactions occurred after the first administration of Cipquin already. In these cases, Cipquin has to be discontinued and the doctor should be informed immediately.
, e.g. rashes. Very Rarely: Pruritus, drug fever. Anaphylactic/anaphylactoid reactions (e.g., facial, vascular and laryngeal oedema; dyspnoea progressing to life-threatening shock. In these cases, Cipquin has to be discontinued and medical treatment (e.g., treatment for shock) is required. Punctate skin haemorrhages (petechiae), blister formation with accompanying haemorrhages (haemorrhagic bullae) and small nodules (papules) with crust formation showing vascular involvement (vasculitis), Stevens-Johnson syndrome, interstitial nephritis, hepatitis; very rarely, major liver disorders, including hepatic necrosis.
Effects on the Cardiovascular System:
Very rarely: Tachycardia, hot flushes, migraine, fainting.
Effects on Blood and Blood Constituents:
Eosinophilia, leucocytopenia, leucocytosis, anaemia; very rarely, thrombocytopenia, thrombocytosis, altered prothrombin levels.
Special senses/sensory organs:
Impaired taste and smell, visual disturbances (e.g. double vision, colour vision), tinnitus & transitory impairment of hearing, especially at high frequencies.
Very rarely: Joint pains, general feeling of weakness, muscular pains, tendovaginitis, mild photosensitivity, transient impairment in kidney function, including transient kidney failure.
Effect on Laboratory Values/Urine Deposits:
There may be a transient rise in the transaminase and alkaline phosphatase levels, or cholestatic jaundice may occur; transient increase in serum urea, creatinine and bilirubin levels, hyperglycaemia; in individual cases: Crystalluria and haematuria.