Class IA or III antiarrhythmics, multivalent cation-containing prep & mineral supplements, polymeric phosphate binders, sucralfate or antacids, highly buffered drugs containing Mg, Al, Ca, dairy products or mineral fortified drinks. Increased serum conc w/ probenecid. Increased serum conc of tizanidine, theophylline, caffeine, pentoxifylline. Increased absorption w/ metoclopramide. Slight reduction of Cmax
& AUC w/ omeprazole. Inhibit renal tubular transport of methotrexate. Induced convulsions w/ NSAIDs. Increased serum creatinine conc w/ cyclosporin. Augmented anticoagulant effects of vit K antagonist. Intensified action of glibenclamide. Increased AUC & Cmax
of duloxetine, ropinirole & sildenafil. Reduced clearance of lidocaine IV.