The following guideline doses are recommended: (See table.)
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Administration: The tablets are swallowed whole with a small amount of fluid.
They can be taken independent of mealtimes, (if the tablets are taken on an empty stomach, the active substance is absorbed more rapidly).
If the patient is unable to take tablets, because of the severity of the illness or for other reasons, it is recommended to commence the therapy with an intravenous form of ciprofloxacin.
Duration of Treatment: The duration of treatment depends on the severity of the illness and on the clinical and bacteriological course. It is essential to continue therapy for at least 3 days after disappearance of the fever or of the clinical symptoms.
Mean Duration of Treatment: 1 day for acute uncomplicated gonorrhea and cystitis; up to 7 days for infections of the kidneys, urinary tract and abdominal cavity; over the entire period of the neutropenic phase in patients with weakened body defences; a maximum of 2 months in osteomyelitis; 7-14 days in all other infections.
In streptococcal infections the treatment must last at least 10 days because of the risk of late complications.
Infections caused by Chlamydia should also be treated for a minimum of 10 days.
Elderly: Elderly patients should receive a dose as low as possible depending on the severity of their illness and the creatinine clearance.
Impaired Renal Function: Where creatinine clearance is between 31 and 60 mL/min/1.73 m2 or where the serum creatinine concentration is between 1.4 and 1.9 mg/100 mL the maximum daily dose should be 1000 mg/day. Where creatinine clearance is ≤ 30 mL/min/1.73 m2 or where the serum creatinine concen tra tion is ≥ 2 mg/100 mL the maximum daily dose should be 500 mg/day.
Impaired Renal Function + Haemodialysis: Dose as Impaired Renal Function; on dialysis days after dialysis.
Impaired Renal Function + CAPD: 500 mg.
Impaired Liver Function: No dose adjustment is required.
Impaired Renal and Liver Function: Dose adjustment as in Impaired Renal Function.
Mode of Administration: Oral.