Clarinase 24 Hr Extended Release

Clarinase 24 Hr Extended Release Overdosage

loratadine + pseudoephedrine

Manufacturer:

Bayer

Distributor:

Zuellig Pharma
Full Prescribing Info
Overdosage
To date, overdosage has not been reported with Clarinase 24 Hr Extended Release. In the event of overdosage, general symptomatic and supportive treatment should be started immediately and maintained for as long as necessary.
Symptoms: These may vary from CNS depression (sedation, apnea, diminished mental alertness, cyanosis, coma, cardiovascular collapse) to stimulation (insomnia, hallucinations, tremors or convulsions) to death. Other signs and symptoms may be euphoria, excitement, tachycardia, palpitations, thirst, perspiration, nausea, dizziness, tinnitus, ataxia, blurred vision and hypertension or hypotension. Stimulation is particularly likely in children, as are atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing; hyperthermia and gastrointestinal symptoms).
In large doses, sympathomimetics may give rise to giddiness, headache, nausea, sweating, thirst, tachycardia, precordial pain, palpitations, difficulty in micturition, muscular weakness, tenseness, anxiety, restlessness and insomnia. Some patients present a toxic psychosis with delusions and hallucinations. Some may develop cardiac arrhythmias, circulatory collapse, convulsions, coma and respiratory failure.
The oral LK50 values for loratadine and pseudoephedrine sulfate in combination product were approximately 600 mg/kg in mice and 2000 mg/kg in rats. Cynomolgus monkeys tolerated single doses of up to 240 mg/kg.
Treatment: The patient should be induced to vomit, even if emesis has occurred spontaneously. Pharmacologically-induced vomiting by the administration of ipecac syrup is a preferred method. However, vomiting should not be induced in patients with impaired consciousness. The action of ipecac is facilitated by physical activity and by the administration of 240-360 mL of water. If emesis does not occur within 15 min, the dose of ipecac should be repeated. Precautions against aspiration must be taken, especially in children. Following emesis, adsorption of any drug remaining in the stomach may be attempted by the administration of activated charcoal as a slurry in water. If vomiting is unsuccessful, or contraindicated, gastric lavage should be performed. Physiologic saline solution is the lavage solution of choice, particularly in children. In adults, tap water can be used; however, as much as possible, the amount administered should be removed before the next instillation. Saline cathartics draw water into the bowel by osmosis and therefore may be valuable for their action in rapid dilution of bowel content. Loratadine is not removed by hemodialysis; it is not known if loratadine is removed by peritoneal dialysis. After emergency treatment, the patient should continue to be medically monitored.
Treatment of the signs and symptoms of overdosage is symptomatic and supportive. Stimulants (analeptic agents) should not be used. Vasopressors may be used to treat hypotension. Short-acting barbiturates, diazepam or paraldehyde may be administered to control seizures. Hyperpyrexia, especially in children, may require treatment with tepid water sponge baths or hypothermic blanket. Apnea is treated with ventilatory support.
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