Clobetasol + Neomycin + Nystatin


Concise Prescribing Info
Indications/Uses
Severe inflammatory skin disorders.
Dosage/Direction for Use
Adult : Topical Per g cream/oint contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100,000 u: Apply 1-2 times/day.
Dosage Details
Topical/Cutaneous
Severe inflammatory skin disorders
Adult: As cream/ointment. Each g contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100 000 units. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Child: >2 yr: As cream/ointment. Each g contains clobetasol propionate 0.5 mg, neomycin sulfate 5 mg and nystatin 100 000 units. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Contraindications
Primary cutaneous viral infections, rosacea, acne vulgaris and perioral dermatitis. Neonates and infants.
Special Precautions
Avoid prolonged treatment. Caution when applied to area near to the eyes. Renal impairment, elderly and children. Pregnancy and lactation.
Adverse Reactions
May cause atrophic changes in the skin e.g. skin thinning, striae and dilatation of superficial blood vessels. Pigmentation and hypertrichosis.
Drug Interactions
If there is substantial systemic absorption, neomycin may prolong and intensify respiratory depressant effects of neuromuscular blockers.
Action
Description: Clobetasol is a highly active corticosteroid that has topical anti-inflammatory action brought about partly by vasoconstriction and reduced collagen synthesis. Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template. Nystatin works by binding to ergosterol in the cell membrane of fungus resulting in a change in the cell wall permeability and leakage of cellular components.
Storage
Store below 25°C.
Disclaimer: This information is independently developed by MIMS based on Clobetasol + Neomycin + Nystatin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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