Dosage should be individually adjusted according to condition.
In general, small doses should be used initially and increased to the optimal effective level as rapidly as possible based on the therapeutic response.
Acute Schizophrenia and Other Acute Psychoses; Severe Acute States of Agitation; Mania:
Oral treatment: Usually 10-50 mg/day. In moderate to severe cases initially 20 mg/day increased, if necessary, by 10-20 mg/day every 2-3 days to ≥75 mg daily.
Chronic Schizophrenia and Other Chronic Psychoses:
Oral treatment: Maintenance dosage 20-40 mg/day.
Agitation in Oligophrenic Patients:
Oral treatment: 6-20 mg/day, if necessary increased to 25-40 mg daily.
Agitation and Confusion in Senile Patients:
Oral treatment: 2-6 mg/day, which can be administered late in the day. If necessary increased to 10-20 mg/day.
Clopixol-Acuphase is administered by IM injection.
The dosage range should normally be 50-150 mg (1-3 mL) IM repeated if necessary, preferably with a time interval of 2-3 days. In a few patients, an additional injection may be needed 24-48 hrs following the 1st injection.
In the maintenance therapy, treatment should be continued with oral Clopixol or Clopixol Depot IM after the following guidelines:
Change to Oral Clopixol: 2-3 days after the last injection of Clopixol-Acuphase, a patient who has been treated with 100 mg Clopixol-Acuphase, oral treatment should be started at a dosage of about 40 mg daily, possibly in divided dosages. If necessary, the dose can be further increased by 10-20 mg every 2-3 days up to 75 mg or more.
Change to Clopixol Depot: Concomitantly with the last injection of Clopixol-Acuphase, a dose of 200-400 mg (1-2 mL) of Clopixol Depot should be given IM and repeated every 2nd week. Higher doses or shorter interval may be needed.
Dosage and interval between injections should be adjusted according to therapeutic response.
Clopixol Depot is administered by IM injection into the upper outer buttock in doses of 200-400 mg at 2- to 4-week intervals. A few patients need higher doses or shorter intervals.
When changing the medication from Clopixol tablet to Clopixol Depot, the following guideline may be used:
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Oral Clopixol should be continued during the 1st week after the 1st injection but in diminishing dosage.