Clotrimazole + Hydrocortisone


Concise Prescribing Info
Indications/Uses
Inflammatory skin fungal infections.
Dosage/Direction for Use
Adult : Topical As 1% cream: Apply thinly and evenly to the affected area bid and rub in gently. Max duration: 7 days. Max: 10 mg/kg; 500 mg for 50 kg adult equivalent to approx 2 cm to be divided into 2 applications/day.
Dosage Details
Topical/Cutaneous
Inflammatory skin fungal infections
Adult: As 1% cream: Apply thinly and evenly to the affected area bid and rub in gently. Max duration: 7 days. Max: 10 mg/kg; 500 mg for 50 kg adult equivalent to approx 2 cm to be divided into 2 applications per day.
Child: Require shorter course of treatment.
Elderly: Use minimum quantity for the shortest duration.
Contraindications
Hypersensitivity. Use on broken skin. Diseases affecting the skin (e.g. acne, perioral dermatitis); any untreated bacterial skin diseases; viral skin diseases (e.g. herpes simplex, chicken pox); dermal vaccination reactions.
Special Precautions
Elderly, childn and infant. Pregnancy and lactation.
Adverse Reactions
Allergic reaction (e.g. syncope, urticaria, dyspnoea, hypotension), blisters, oedema, discomfort/pain, erythema, peeling/exfoliation, irritation. Rarely, hypothalamic-pituitary adrenal axis suppression, cushingoid features, delayed wt gain/growth retardation in childn, glaucoma, HTN, hyperglycaemia/glucosuria, osteoporosis, cataract, increased wt/obesity, decreased endogenous cortisol levels, steroid withdrawal syndrome.
Patient Counseling Information
Do not apply on large areas (>5-10% of the body surface), under occlusive dressings (e.g. nappies and bandages). Do not use in long-term continuous therapy. May damage latex contraceptives.
Drug Interactions
May reduce effectiveness of contraceptives.
Action
Description: Clotrimazole inhibits ergosterol synthesis, which leads to structural and functional impairment of fungal cytoplasmic membrane. Hydrocortisone, a weak corticosteroid w/ both glucocorticoid and to a lesser extent mineralocorticoid activity, has antiphlogistic, antipruriginous, antiexudative and antiallergic effects.
Pharmacokinetics:
Absorption: Clotrimazole: Penetrates the epidermis w/ a little systemic absorption. Absorbed 3-10% of a dose (vag use). Hydrocortisone: Absorbed through the skin particularly in denuded areas.
Distribution: Hydrocortisone: Plasma protein binding: >90%.
Metabolism: Clotrimazole: Hepatically metabolised to inactive compounds. Hydrocortisone: Metabolised in the liver and tissues.
Excretion: Clotrimazole: Via faeces and urine. Hydrocortisone: Via urine. Biological half-life: Approx 100 min.
Chemical Structure

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Storage
Store below 25°C.
MIMS Class
ATC Classification
D01AC - Imidazole and triazole derivatives ; Used in the topical treatment of fungal infection.
Disclaimer: This information is independently developed by MIMS based on Clotrimazole + Hydrocortisone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
  • Canesten HC
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