ipratropium bromide + salbutamol


Boehringer Ingelheim


Concise Prescribing Info
Per UDV Ipratropium Br 0.5 mg, salbutamol sulfate 2.5 mg
Management of reversible bronchospasm associated w/ obstructive airway disease in patients who require more than a single bronchodilator.
Dosage/Direction for Use
Adult including elderly Acute attacks 1 unit-dose vial. Severe cases May require 2nd unit-dose vial to be administered. Maintenance: 1 unit-dose vial tds or qds.
Hypersensitivity to atropine. Hypertrophic obstructive cardiomyopathy or tachyarrhythmia.
Special Precautions
Immediate hypersensitivity reactions. Discontinue if paradoxical bronchospasm occurs. Acute, rapidly worsening dyspnoea. Patients predisposed to glaucoma, insufficiently controlled DM, recent MI, severe organic heart or vascular disorders, underlying severe heart disease, hyperthyroidism, phaeochromocytoma, risk of narrow-angle glaucoma, prostatic hypertrophy or bladder-neck obstruction, hypoxia, cystic fibrosis. Hypokalaemia. May affect ability to drive & use machines. Hepatic or renal insufficiency. Pregnancy & lactation. Childn.
Adverse Reactions
Headache, throat irritation, cough, dry mouth, GI motility disorders eg, constipation, diarrhea & vomiting, nausea & dizziness.
Drug Interactions
Increased side effects w/ xanthine derivatives, other β-adrenergics & anticholinergics. Increased β2-agonist induced hypokalaemia w/ glucocorticosteroids & diuretics. Increased susceptibility to arrhythmia w/ digoxin. Potentially serious reduction in bronchodilator effects w/ β-blockers. Enhanced β-adrenergic agonists action w/ MAOIs & TCAs. Increased susceptibility to CV effects of β-agonists w/ halogenated hydrocarbon anaesth eg, halothane, trichloroethylene & enflurane.
ATC Classification
R03AL02 - salbutamol and ipratropium bromide ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
Combivent inhalant (unit-dose vial)
2.5 mL x 20 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in