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Combivent

Combivent

ipratropium bromide + salbutamol

Manufacturer:

Boehringer Ingelheim

Distributor:

DKSH
Concise Prescribing Info
Contents
Per UDV Ipratropium Br 0.5 mg, salbutamol sulfate 2.5 mg
Indications/Uses
Management of reversible bronchospasm associated w/ obstructive airway disease in patients who require more than a single bronchodilator.
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Dosage/Direction for Use
Adult including elderly Acute attacks 1 unit-dose vial. Severe cases May require 2nd unit-dose vial to be administered. Maintenance: 1 unit-dose vial tds or qds.
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Overdosage
View Combivent overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to atropine. Hypertrophic obstructive cardiomyopathy or tachyarrhythmia.
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Special Precautions
Immediate hypersensitivity reactions. Discontinue if paradoxical bronchospasm occurs. Acute, rapidly worsening dyspnoea. Patients predisposed to glaucoma, insufficiently controlled DM, recent MI, severe organic heart or vascular disorders, underlying severe heart disease, hyperthyroidism, phaeochromocytoma, risk of narrow-angle glaucoma, prostatic hypertrophy or bladder-neck obstruction, hypoxia, cystic fibrosis. Hypokalaemia. May affect ability to drive & use machines. Hepatic or renal insufficiency. Pregnancy & lactation. Childn.
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Adverse Reactions
Headache, throat irritation, cough, dry mouth, GI motility disorders eg, constipation, diarrhea & vomiting, nausea & dizziness.
Drug Interactions
Increased side effects w/ xanthine derivatives, other β-adrenergics & anticholinergics. Increased β2-agonist induced hypokalaemia w/ glucocorticosteroids & diuretics. Increased susceptibility to arrhythmia w/ digoxin. Potentially serious reduction in bronchodilator effects w/ β-blockers. Enhanced β-adrenergic agonists action w/ MAOIs & TCAs. Increased susceptibility to CV effects of β-agonists w/ halogenated hydrocarbon anaesth eg, halothane, trichloroethylene & enflurane.
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Storage
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Description
View Combivent description for details of the chemical structure and excipients (inactive components).
Action
View Combivent mechanism of action for pharmacodynamics and pharmacokinetics details.
ATC Classification
R03AL02 - salbutamol and ipratropium bromide ; Belongs to the class of combination of adrenergics with anticholinergics, that may also include a corticosteroid. Used in the treatment of obstructive airway diseases.
Presentation/Packing
Form
Combivent inhalant (unit-dose vial)
Packing/Price
2.5 mL x 20 × 1's
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