Copper sulfate


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Nutritional deficiency As elemental copper: 900 mcg/day. Max: 10 mg/day. IV Nutritional deficiency As elemental copper: 0.5-1.5 mg/day via TPN. Copper deficiency As elemental copper: 3 mg/day.
Dosage Details
Intravenous
Nutritional deficiency
Adult: TPN 0.5-1.5 mg/day of elemental copper.
Child: TPN Full-term infants & childn 20 mcg elemental copper/kg/day IV. May be added to TPN.

Intravenous
Copper deficiency
Adult: 3 mg/day of elemental copper. May be added to TPN.
Child: Full-term infants & childn 20-30 mcg/kg/day IV of elemental copper. May be added to TPN.

Oral
Nutritional deficiency
Adult: As elemental copper. 900 mcg/day (max: 10 mg/day). Pregnant females 1 mg/day. Lactating females 1.3 mg/day. Adolescents ≥14 yr 890 mcg/day (max: 8 mg/day) .
Child: Birth-6 mth 200 mcg/day. 7-12 mth 220 mcg/day. 1-3 yr 340 mcg/day (max: 1 mg/day). 4-8 yr 440 mcg/day (max: 3 mg/day). 9-13 yr 700 mcg/day (max: 5 mg/day).
Special Precautions
Young children. Pregnancy, lactation. Wilson's disease. Chronic liver/renal failure. Hepatic impairment: copper may accumulate if biliary obstruction or hepatic disease is present.
Adverse Reactions
Excessive dose may cause abdominal pain or cramps, diarrhoea, nausea/vomiting & metallic taste.
Overdosage
Severe GI effects. In extreme or long term overdosage, symptoms may be similar to that of Wilson's disease. Treatment is symptomatic and may involve the use of a chelating agent (e.g. penicillamine, trientine and zinc) to remove any absorbed metal. Dialysis may be useful.
Drug Interactions
Ascorbic acid (large doses). Inhibit intestinal absorption by oral iron supplements, oral/parenteral Zn, D-Penicillamine or trientine chelate copper. Excessive amounts of molybdenum may produce copper deficiency.
Food Interaction
Concomitant intake with foods rich in phytic acid (unleavened bread, raw beans, seeds, nuts & grains & soy isolates) may decrease absorption of copper. Diets high in fructose may decrease copper status.
Action
Description: An essential trace element important for proper functioning of many metalloenzymes including ceruloplasmin, ferroxidase II, lysyl oxidase, monoamine oxidase, Zn-copper superoxide dismutase, tyrosinase, dopamine-β-hydroxylase & cytochrome-c-oxidase. It is involved in erythropoiesis & leukopoiesis, bone mineralisation, elastin & collagen cross-linking, oxidative phosphorylation, catecholamine metabolism, melanin formation & antioxidant protection of cells. May also play a role in iron turnover, ascorbic acid metabolism, phospholipid metabolism, myelin formation, glucose homeostasis & cellular immune defense.
Pharmacokinetics:
Absorption: Principally absorbed in the small intestine.
Excretion: 80% eliminated via the bile. Little excretion by the kidney.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Copper sulfate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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