Corticorelin


Concise Prescribing Info
Indications/Uses
Diagnostic test in differentiating pituitary and ectopic production of ACTH.
Dosage/Direction for Use
Adult : IV 1 mcg/kg via inj over 30-60 sec.
Dosage Details
Intravenous
Diagnostic test in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome
Adult: 1 mcg/kg via inj over 30-60 sec. Obtain venous blood samples 15 min prior to inj to determine baseline ACTH and cortisol levels, and at 15, 30, and 60 min after inj to evaluate ACTH and cortisol response. In response to corticorelin, patients w/ high basal plasma ACTH and cortisol (20-40 mcg/dL) will have an exaggerated increase in plasma ACTH and cortisol levels indicating pituitary production of ACTH (Cushing’s syndrome) while patients w/ high basal plasma ACTH (may be very high) and high basal plasma cortisol will have little or no response, indicating ectopic production of ACTH.
Child: Same as adult dose.
Reconstitution
Reconstitute w/ 2 mL of NaCl 0.9% to provide a soln containing 50 mcg/mL. Do not shake. Roll the vial to dissolve.
Contraindications
Hypersensitivity to ovine corticorelin.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Significant: Hypersensitivity reactions (e.g. urticaria, dyspnoea, wheezing, angioedema, flushing of the face, neck, and upper chest), transient tachycardia, hypotension, syncope, asystole.
Nervous: Tonic-clonic seizures, dizziness.
CV: Decreased BP, palpitations.
GI: Metallic taste, xerostomia, vomiting.
IV/Parenteral: C
MonitoringParameters
Monitor BP, heart rate, and signs and symptoms of hypersensitivity reactions.
Overdosage
Symptoms: Severe facial flushing, CV changes, dyspnoea. Management: Symptomatic treatment.
Drug Interactions
Pretreatment w/ dexamethasone may inhibit plasma ACTH response to corticorelin. May cause major hypotensive reaction w/ heparin.
Action
Description: Corticorelin, an ovine corticotropin-releasing hormone (oCRH) peptide and an analogue of human CRH (hCRH) peptide, is used for the determination of pituitary corticotroph responsiveness. It acts on the anterior pituitary, stimulating the release of adrenocorticotropic hormone (ACTH), which is responsible for the production of cortisol from the adrenal cortex.
Onset: Elevation of plasma ACTH level: 2 min. Elevation of plasma cortisol level: W/in 10 min.
Duration: Plasma ACTH/cortisol levels: Up to 2 hr.
Pharmacokinetics:
Absorption: Time to peak plasma concentration (biphasic): Initial: ACTH: 15-60 min; cortisol: 30-120 min. 2nd: 2-3 hr,
Distribution: Volume of distribution: 6.2 ±0.5 L.
Excretion: Elimination half-life: Slow component: 73 ±8 min; fast component: 11.6 ±1.5 min.
Storage
Store between 2-8°C. Protect from light.
ATC Classification
V04CD04 - corticorelin ; Belongs to the class of diagnostic agents used to test for pituitary function.
References
Acthrel Injection, Powder, Lyophilized, for Solution (Ferring Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/07/2017.

Anon. Corticorelin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/07/2017.

Buckingham R (ed). Corticorelin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/07/2017.

Disclaimer: This information is independently developed by MIMS based on Corticorelin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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