Cosentyx

Cosentyx

secukinumab

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Secukinumab
Indications/Uses
Moderate to severe plaque psoriasis in patients ≥6 yr who are candidates for systemic therapy or phototherapy. Alone or in combination w/ MTX for active psoriatic arthritis in adults when previous DMARDs therapy has been inadequate. Active ankylosing spondylitis in adults who have responded inadequately to conventional therapy. Active non-radiographic axial spondyloarthritis (nr-axSpA) w/ objective signs of inflammation as indicated by elevated C-reactive protein (CRP) &/or MRI evidence in adults who responded inadequately to NSAIDs.
Dosage/Direction for Use
Plaque psoriasis & psoriatic arthritis patient who are anti-TNFα inadequate responders or patient w/ concomitant moderate to severe plaque psoriasis 300 mg SC inj given in 2 doses w/ initial dosing at wk 0, 1, 2, 3 & 4, followed by mthly maintenance dosing. Psoriatic arthritis, ankylosing spondylitis & nr-axSpA 150 mg SC inj w/ initial dosing at wk 0, 1, 2, 3 & 4, followed by mthly maintenance dosing.
Contraindications
Severe hypersensitivity reactions.
Special Precautions
Discontinue use if anaphylactic or other serious allergic reaction occurs. Not to be given in active TB patients. Patients w/ chronic or history of recurrent infection; active inflammatory bowel disease (eg, Crohn's disease & ulcerative colitis). Latex-sensitive individuals. Not to be given concurrently w/ live vaccines. Pregnancy & lactation. Ped <18 yr; ped w/ plaque psoriasis <6 yr.
Adverse Reactions
URTIs eg, nasopharyngitis, rhinitis, pharyngitis. Oral herpes; rhinorrhoea; diarrhoea; urticaria.
Drug Interactions
Not to be given concurrently w/ live vaccines.
MIMS Class
Disease-Modifying Anti-Rheumatic Drugs (DMARDs) / Immunosuppressants / Psoriasis, Seborrhea & Ichthyosis Preparations
ATC Classification
L04AC10 - secukinumab ; Belongs to the class of interleukin inhibitors. Used as immunosuppressants.
Presentation/Packing
Form
Cosentyx soln for inj (pre-filled pen) 150 mg/mL
Packing/Price
1's;2 × 1's
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