HIGHLIGHT
Cosyrel

Cosyrel Dosage/Direction for Use

Manufacturer:

Servier

Distributor:

Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
Posology: The usual posology is one tablet once daily.
Patients should be stabilized with bisoprolol and perindopril at the same dose level for at least 4 weeks. The fixed dose combination is not suitable for initial therapy.
For patients stabilized with bisoprolol 2.5 mg and perindopril 2.5 mg: one half 5 mg/5 mg tablet once daily.
For patients stabilized with bisoprolol 2.5 mg and perindopril 5 mg: one half 5 mg/10 mg tablet once daily.
If a change of posology is required, titration should be done with the individual components.
Special population: Renal impairment (see Precautions and Pharmacology: Pharmacokinetics under Actions): In patients with renal impairment, the recommended dose of Cosyrel 5 mg/5 mg and Cosyrel 5 mg/10 mg should be based on creatinine clearance as outlined in table 1 as follows: See Table 1.

Click on icon to see table/diagram/image

Cosyrel 10 mg/10 mg is not suitable for patients with renal impairment. In these patients, an individual dose titration with the monocomponents is recommended.
Hepatic impairment (see Precautions and Pharmacology: Pharmacokinetics under Actions): No dosage adjustment is necessary in patients with hepatic impairment.
Elderly: Cosyrel should be administered according to the renal function.
Paediatric population: The safety and efficacy of Cosyrel in children and adolescents have not been established. No data are available. Therefore, use in children and adolescents is not recommended.
Method of administration: Cosyrel tablet should be taken as a single dose once daily in the morning before a meal.
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