Covinace

Covinace

perindopril

Manufacturer:

Pharmaniaga Manufacturing Berhad

Distributor:

Pharmaniaga Logistics
Concise Prescribing Info
Contents
Perindopril tert-butylamine
Dosage/Direction for Use
HTN 4 mg in the morning, may be increased to 8 mg after 1 mth. Elderly 2 mg in the morning, may be increased to 4 mg after 1 mth. CHF 2 mg in the morning, may be increased to 4 mg after 15 days. CrCl between 30 & 60 mL/min 2 mg daily, CrCl between 15 & 30 mL/min 2 mg every other day, CrCl <15 mL/min 2 mg on dialysis day.
Administration
Should be taken on an empty stomach.
Contraindications
2nd & 3rd trimesters of pregnancy. Lactation. Childn.
Special Precautions
Risk of arterial hypotension; renovascular HTN. Patients undergoing major surgery or during anaesth. W/draw diuretic at least 3 days prior to initiation in hypertensive patients previously treated w/ diuretic. Perform plasma creatinine assay prior & during treatment. Renal failure. Elderly.
Adverse Reactions
Headache, mood &/or sleep disturbances, asthenia, GI disorders, skin rash.
Drug Interactions
Induced hyperkalemia w/ K supplements or K-sparing diuretics. Severe initial fall in BP w/ diuretics. Increased risk of orthostatic hypotension w/ neuroleptic or TCAs.
MIMS Class
ACE Inhibitors/Direct Renin Inhibitors
ATC Classification
C09AA04 - perindopril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Covinace tab 4 mg
Packing/Price
3 × 10's
Form
Covinace tab 8 mg
Packing/Price
3 × 10's
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