Covinace Adverse Reactions



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Adverse Reactions
Reported side effects are rare and benign. The most frequent complaints were often reported at the start of treatment, when blood pressure was poorly controlled: headaches, mood and/or sleep disturbances, asthenia.
Non-specific gastrointestinal disorders, such as taste disturbances, dizziness and cramps have been reported. Several localised skin rashes were also noted. A non-productive, irritating, dry cough were sometimes observed, though this caused little discomfort. Several other relatively non-specific side effects were often reported during multiple-agent therapy: sexual disorders, dryness of the mouth.
As far as the laboratory findings are concerned, a very slight reduction in haemoglobin was sometimes observed at the start of treatment. A slight increase in blood potassium levels, which returned to normal on combination with a hypokalemia diuretic, has been reported. Elevated blood urea and creatinine, reversible on interruption of treatment, was also observed.
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