Covinace Special Precautions



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Special Precautions
Renal failure: In the renal failure, the dosage of perindopril must be adjusted according to the degree of renal insufficiency.
In these patients, normal medical practice involves periodic testing of blood potassium and creatinine.
The recommended dosages are as follows: (See table.)

Click on icon to see table/diagram/image

Renovascular hypertension: The correct treatment for renovascular hypertension is revascularization.
Nevertheless, perindopril may be use in patients presenting renovascular hypertension and awaiting corrective surgery or when surgery is impossible. Treatment must then be instituted with care (see Warnings) and renal function must be continually monitored.
Therapy during anaesthesia: In cases of anaesthesia for major surgery, or during anaesthesia achieved with potentially hypotensive agents, perindopril may induce hypotension which must be corrected by increasing blood volume.
Use in Elderly: Treatment should be instituted at the dosage of 2 mg per day in a single dose and renal function must be evaluated before starting treatment.
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