Cozaar XQ

Cozaar XQ

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 5/50 mg tab Amlodipine camsylate 5 mg, losartan K 50 mg. Per 5/100 mg tab Amlodipine camsylate 5 mg, losartan K 100 mg
Indications/Uses
Essential HTN in adult patients whose BP is not adequately controlled on either monotherapy.
Dosage/Direction for Use
1 tab daily. HTN 5/50 mg in patient whose BP is not adequately controlled w/ amlodipine 5 mg or losartan 50 mg alone, or 5/100 mg in patient whose BP is not adequately controlled w/ losartan 100 mg or 5/50 mg dose. Max recommended dose: 5/100 mg.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Hypotension; hypersensitivity (angioedema) & electrolyte/fluid imbalance (losartan); increased angina or MI & patients w/ heart failure (amlodipine). May impair ability to drive or operate machinery. Hepatic & renal impairment. Pregnancy & lactation. Patients ≤18 yr.
Adverse Reactions
Dizziness, headache, fatigue, vertigo, edema. Somnolence; asthenia, chest discomfort & pain, early satiety, peripheral & pitting edema; abdominal discomfort, dyspepsia, nausea, reflux esophagitis; generalized pruritus & urticaria; palpitation; flushing, orthostatic hypotension; dyspnea; vertigo; pollakiuria.
Drug Interactions
Losartan: Reduced active metabolite levels by rifampicin & fluconazole. Increased serum potassium by K-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements or K containing salt-substitutes. Reduced lithium excretion. Reduced effects of diuretics & other antihypertensives. Further renal function deterioration by AIIA & ACE inhibitors. Amlodipine: Increased plasma by strong CYP3A4 inhibitors.
ATC Classification
C09DB06 - losartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Cozaar XQ 5/100 mg FC tab
Packing/Price
10's;30's
Form
Cozaar XQ 5/50 mg FC tab
Packing/Price
10's;30's
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