1 tab daily. HTN 5/50 mg in patient whose BP is not adequately controlled w/ amlodipine 5 mg or losartan 50 mg alone, or 5/100 mg in patient whose BP is not adequately controlled w/ losartan 100 mg or 5/50 mg dose. Max recommended dose: 5/100 mg.
Losartan: Reduced active metabolite levels by rifampicin & fluconazole. Increased serum K by K-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements or K containing salt-substitutes. Reduced lithium excretion. Reduced effects of diuretics & other antihypertensives. Further renal function deterioration by AIIA & ACE inhibitors. Amlodipine: Increased plasma by strong CYP3A4 inhibitors.
C09DB06 - losartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
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