Cozaar XQ

Cozaar XQ Description

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Full Prescribing Info
Description
Each 5/50 mg film-coated tablet contains losartan potassium 50 mg equivalent to losartan 45.8 mg and amlodipine camsylate equivalent to amlodipine 5 mg.
Each 5/100 mg film-coated tablet contains losartan potassium 100 mg equivalent to losartan 91.5 mg and amlodipine camsylate equivalent to amlodipine 5 mg.
It also contains the following excipients: Butylated hydroxytoluene, sodium starch glycollate, microcrystalline cellulose, D-mannitol, povidone, crospovidone, magnesium stearate, hypromellose, hydroxypropylcellulose, titanium oxide and talc.
Losartan Potassium: Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4yl]methyl]-1H-imidazole-5-methanol monopotassium salt. Its empirical formula is C22H22ClKN6O.
Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents eg, acetonitrile and methyl ethyl ketone.
Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.
Amlodipine Camsylate: Amlodipine camsylate is chemically described as 3-ethyl 5-methyl (4RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate camphor sulfonate. Its empirical formula is C20H25ClN2O5·C10H16O4S.
Amlodipine camsylate is a white to slightly yellow crystalline powder with a molecular weight of 1049.32. It is freely soluble in chloroform, dimethylformamide and dimethylsulfoxide, and slightly soluble in water, ethanol and methylenechloride.
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