Cozaar XQ

Cozaar XQ Dosage/Direction for Use

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
Recommended Dosage: 1 tab daily.
Treatment of Hypertension: Losartan: 50-100 mg once daily. Amlodipine: 5-10 mg as monotherapy. Maximum Recommended Dosage: 5/100 mg.
A patient whose blood pressure is not adequately controlled with losartan alone or amlodipine alone may be switched to combination therapy with Cozaar XQ.
Cozaar XQ 5/50 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 5 mg or losartan 50 mg alone.
Cozaar XQ 5/100 mg may be administered in patients whose blood pressure is not adequately controlled with amlodipine 5 mg or losartan 100 mg or Cozaar XQ 5/50 mg.
A patient co-administered with losartan and amlodipine may be switched to Cozaar XQ (fixed dose combination containing same dose of each ingredient) for compliance improvement.
Elderly: Because of decreased clearance in the elderly, amlodipine therapy should usually be initiated at 2.5 mg daily. Since amlodipine 2.5 mg dose is not available with Cozaar XQ, this dose should be achieved with amlodipine monotherapy.
Patients with Renal Impairment: No dosage adjustment is necessary in patients with mild renal impairment [ie, creatinine clearance (CrCl) 20-50 mL/min]. Moderate to severe renal impairment (ie, CrCl <20 mL/min) or patients on dialysis, administration of Cozaar XQ is not recommended.
Patients with Intravascular Volume Depletion (eg, Those Treated with High-Dose Diuretics): Starting Dose: Losartan 25 mg once daily should be considered (see Precautions). Since losartan 25-mg dose is not available with Cozaar XQ, this dose should be achieved with losartan monotherapy.
Patients with Hepatic Impairment: In cases where a lower dose of losartan (ie, 25 mg once daily) is required for patients with a history of hepatic impairment, administration of Cozaar XQ is not recommended.
Administration: Cozaar XQ may be administered with or without food. It is recommended to take Cozaar XQ with water.
Cozaar XQ may be administered with other antihypertensive agents.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in