CV disease, HTN, hyperthyroidism; CNS disturbances; Down's syndrome. Determine IOP prior to initiation of therapy. Light sensitivity. May cause irritation due to benzalkonium Cl. Avoid contact w/ soft contact lens. Remove contact lens prior to application & wait 15 min before reinsertion. Febrile patients exposed to elevated environmental temp. May affect ability to drive & use machines. Pregnancy & lactation. Infants, young childn, childn w/ epilepsy, spastic paralysis or brain damage. High-dose use especially in elderly.