Cytarabine Pfizer

Cytarabine Pfizer





Zuellig Pharma
Concise Prescribing Info
Induction & maintenance of remission in acute myelocytic leukaemia in adult & childn. Other leukemias eg, acute lymphocytic leukaemia, chronic myelocytic leukaemia (blast phase).
Dosage/Direction for Use
Adult Monotherapy Up to 200 mg/m2 as continuous IV infusion for 5 days repeated at approx 2-wkly intervals. Meningeal leukaemia 30 mg/m2 intrathecally every 4 days until CSF findings are normal, followed by 1 additional treatment. Dose range: 5-75 mg/m2 once daily for 4 days to once every 4 days.
Special Precautions
Anaphylactic reactions. Bone marrow suppression w/ leukopenia, thrombocytopenia & anaemia; preexisting drug-induced bone marrow suppression. Intrathecal use may increased risk of spinal cord toxicity. Acute pancreatitis; vomiting; conventional & experimental dose schedules. Periodic checking of bone marrow exam, liver & kidney functions. Monitor blood uric acid levels. Avoid use w/ live vaccines. Preexisting hepatic dysfunction or poor renal function. Not recommended during pregnancy. Lactation. Severe neurological AR in juveniles & adolescents.
Adverse Reactions
Sepsis, pneumonia, infection; bone marrow failure, thrombocytopenia, anaemia, megaloblastic anaemia, leukopenia, decreased reticulocyte count; stomatitis, mouth ulceration, anal ulcer & inflammation, diarrhoea, vomiting, nausea, abdominal pain; abnormal hepatic function; alopecia, rash; cytarabine syndrome; pyrexia; abnormal bone marrow biopsy & blood smear test. Anorexia; bleeding, thrombophlebitis; skin ulceration. Cerebral & cerebellar disorder, somnolence; haemorrhagic conjunctivitis, corneal disorder; acute resp distress syndrome, pulmonary oedema. Necrotising colitis; skin rash leading to desquamation.
Drug Interactions
Reduced effectiveness of MTX. Decreased steady-state plasma digoxin conc. Antagonised K pneumoniae strains w/ gentamicin. Potential competitive inhibition uptake of fluorocytosine. Physically incompatible w/ heparin, insulin, fluorouracil, methylprednisolone Na succinate, penicillins eg, oxacillin, penicillin G Na.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01BC01 - cytarabine ; Belongs to the class of antimetabolites, pyrimidine analogues. Used in the treatment of cancer.
Cytarabine Pfizer soln for inj 100 mg/mL
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