Cytarabine Pfizer

Cytarabine Pfizer Overdosage

cytarabine

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Full Prescribing Info
Overdosage
There is no antidote for cytarabine overdosage. Doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours for 12 doses has caused an unacceptable increase in irreversible CNS toxicity and death. Symptoms of overdose include nausea, vomiting, diarrhoea, ulceration and bleeding of the gastrointestinal tract, myelosuppression, severe skin rash, CNS toxicity (including cerebral and cerebellar dysfunction), cardiac disorders, pulmonary and corneal toxicity, fever, myalgia, bone pain, chest pain and conjunctivitis.
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