Not as emergency treatment for relief of acute bronchospasm. Monitor body wt regularly. Severe immunological disease & acute infections, cancers (except basal cell carcinoma). Latent infections eg, TB, viral hepatits, herpes viral infection & herpes zoster. Not recommended in patients w/ CHF (NYHA grades III & IV) & history of depression associated w/ suicidal ideation or behavior. Black, non-smoking females. Concomitant use w/ CYP1A2/2C19/3A4 inhibitors, immunosuppressants; theophylline. Galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption. Mild hepatic impairment. Not recommended in women of childbearing potential not using contraception. Not recommended during pregnancy. Not to be used during lactation.