DBL Aciclovir

DBL Aciclovir





Zuellig Pharma


Concise Prescribing Info
Acyclovir Na
Promoting resolution of acute clinical manifestations of mucocutaneous HSV infections in immunocompromised patients. Severe 1st episode primary or non-primary genital herpes in immune competent patients, acute manifestations of varicella zoster virus infection in immunocompromised patients, shingles (varicella zoster virus infection) in immune competent patients who show very severe acute local or systemic manifestations of the disease, herpes simplex encephalitis.
Dosage/Direction for Use
Adult Herpes simplex & very severe herpes zoster infection (shingles) 5 mg/kg every 8 hr. Varicella zoster infection in immunocompromised patient 10 mg/kg every 8 hr. Herpes simplex encephalitis 10 mg/kg every 8 hr. Duration of treatment: Most infections 5-7 days. Herpes simplex encephalitis At least 10 days. CrCl 25-50 mL/min 5 or 10 mg/kg every 12 hr, 10-25 mL/min 5 or 10 mg/kg every 24 hr, 0-10 mL/min 2.5 or 5 mg/kg every 24 hr & after dialysis. Childn 1-12 yr Herpes simplex (except herpes simplex encephalitis) or varicella zoster infection 250 mg/m2. Immunocompromised childn w/ varicella zoster virus infection or herpes simplex encephalitis 500 mg/m2.
Hypersensitivity to aciclovir, valaciclovir.
Special Precautions
Not to be inj as rapid or bolus IV inj, IM or SC. Severe local inflammatory reactions. Patients w/ underlying neurological abnormalities, significant hypoxia or serious electrolyte abnormalities; thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Development of resistant HSV strains. Manifestations of neurological reactions to cytotoxic drugs. Concomitant use of other nephrotoxic drugs, interferon or intrathecal methotrexate. Ensure adequate hydration. Renal impairment, preexisting renal disease. Hepatic impairment. Not to be used during pregnancy. Lactation. Elderly.
Adverse Reactions
Local inj site inflammation; inj site phlebitis; nausea & vomiting; elevation of transaminases, rapid increased in serum urea nitrogen & creatinine; hives, itching, rashes.
Drug Interactions
Increased AUC & reduced renal clearance by probenecid & cimetidine. Increased plasma AUC of mycophenolate mofetil. Additive nephrotoxicity w/ cyclosporin. Increased plasma levels by diuretics. Profound lethargy w/ zidovudine.
MIMS Class
ATC Classification
J05AB01 - aciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
DBL Aciclovir infusion 25 mg/mL
10 mL x 1's;20 mL x 1's
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