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DBL Calcium Folinate

DBL Calcium Folinate

calcium folinate

Manufacturer:

Pfizer

Distributor:

DKSH
Concise Prescribing Info
Contents
Ca folinate
Indications/Uses
Diminish toxicity & counteract effects of folic acid antagonist inadvertent overdosage; as rescue after high-dose MTX therapy. Megaloblastic anaemia due to sprue, nutritional deficiency, pregnancy & infancy when oral therapy is not possible. In combination w/ fluorouracil to prolong survival of patients w/ advanced CRC.
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Dosage/Direction for Use
Leucovorin Ca rescue in impaired MTX elimination or inadvertent overdosage 10 mg/m2 IV or IM every 6 hr until serum MTX level is <10-8 M. If 24 hr serum creatinine >50% or MTX level is >5 x 10-6 M or 48 hr level is >9 x 10-7 M, increase dose to 100 mg/m2 IV every 3 hr until MTX level is <10-8 M. Leucovorin Ca rescue after high-dose MTX therapy 15 mg every 6 hr for 10 doses starting 24 hr after MTX infusion until MTX level is <5 x 10-8 M. Megaloblastic anaemia due to folic acid deficiency Up to 1 mg daily. Advanced CRC 200 mg/m2 by slow IV inj over min of 3 min, followed by 5-fluorouracil 370 mg/m2 by IV inj or 20 mg/m2 by IV inj followed by 5-fluorouracil 425 mg/m2 by IV inj for 5 days. May be repeated at 4-wk (28 days) intervals for 2 courses & then repeated at 4-5 wk (28-35 days) intervals provided that patient has completely recovered.
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Overdosage
View DBL Calcium Folinate overdosage for action to be taken in the event of an overdose.
Contraindications
Pernicious anaemia & other megaloblastic anaemias secondary to lack of vit B12.
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Special Precautions
Not to be administered intrathecally. Not to be initiated or maintained in patients w/ GI toxicity symptoms. Not recommended in patients w/ recurrent neurological symptoms on rechallenge w/ folinic acid. Not to use folinic acid in in hydrocarbamide, cytarabine, mercaptopurine, thioguanine macrocytosis. Not suitable for pernicious anaemias & other anaemias resulting from lack of vit B12. Severe enterocolitis, diarrhoea & dehydration; CNS metastases. Decreased membrane transport. Monitor Ca levels. Not to be mixed w/ fluorouracil in same IV inj or infusion. Avoid excessive folinic acid doses. Pre-existing or MTX-induced renal insufficiency. Not to be used during pregnancy. Lactation. Elderly or debilitated patients.
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Adverse Reactions
Insomnia, agitation, depression after high doses; increased epileptic attacks frequency; abdominal pain; stomatitis, nausea, vomiting, diarrhoea.
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Drug Interactions
Counteracted antiepileptic effect of phenobarb, phenytoin, primidone, succinimides. Reduced efficacy of intrathecally administered MTX. Enhanced toxicity of fluorouracil. Reduced or completely neutralized efficacy of folic acid antagonist co-trimoxazole, pyrimethamine. Incompatibility w/ MTX, fluorouracil droperidol, fosacarnet, phosphonosulphate inj.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view DBL Calcium Folinate detailed prescribing information
Storage
View DBL Calcium Folinate storage conditions for details to ensure optimal shelf-life.
Description
View DBL Calcium Folinate description for details of the chemical structure and excipients (inactive components).
Action
View DBL Calcium Folinate mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Antidotes & Detoxifying Agents
ATC Classification
V03AF03 - calcium folinate ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
Presentation/Packing
Form
DBL Calcium Folinate inj 10 mg/mL
Packing/Price
30 mL x 1's
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