DBL Cisplatin

DBL Cisplatin

cisplatin

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Cisplatin
Indications/Uses
Monotherapy or combination therapy for palliative treatment of metastatic non-seminomatous germ cell carcinoma, advanced stage refractory ovarian & bladder carcinoma & refractory squamous cell head & neck carcinoma.
Dosage/Direction for Use
Adult & childn 50-100 mg/m2 as single IV infusion every 3-4 wk or 15-20 mg/m2 daily as IV infusion for 5 days every 3-4 wk.
Contraindications
Hypersensitivity to cisplatin- or other platinum-containing compd. Hearing impairment or myelosuppression. Renal impairment. Pregnancy & lactation.
Special Precautions
Anaphylactic-like reactions, history of atopy. Patients previously exposed to infections particularly chickenpox & herpes zoster. Performing invasive procedures. Hypomagnesaemia & hypocalcaemia; peripheral neuropathy, postural hypotension, seizures. Cumulative ototoxicity. Measure BUN, serum creatinine & CrCl prior to & during treatment. Perform peripheral blood counts, neurological exam & monitor electrolytes at regular intervals. Monitor liver function periodically. Avoid concomitant use of alcohol & aspirin. Not to be used w/ live vaccines. Avoid dental work during treatment. Hepatic impairment. Renal impairment, preexisting renal dysfunction. Avoid use during pregnancy. Not to be used during lactation.
Adverse Reactions
Tinnitus &/or high frequency hearing loss. Severe nausea & vomiting. Hypomagnesaemia & hypocalcaemia. Anaphylactic-like reactions ie, facial oedema, wheezing, tachycardia & hypotension.
Drug Interactions
Potentiated nephrotoxic & ototoxic effects w/ aminoglycosides & loop diuretics. Increased risk of GI bleeding w/ alcohol & aspirin. Live virus vaccines. Black precipitate formation w/ Al. Affected stability w/ bisulphite, metabisulphite, Na bicarbonate & fluorouracil.
MIMS Class
Cytotoxic Chemotherapy
ATC Classification
L01XA01 - cisplatin ; Belongs to the class of platinum-containing antineoplastic agents. Used in the treatment of cancer.
Presentation/Packing
Form
DBL Cisplatin inj 1 mg/mL
Packing/Price
50 mL x 1's
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