DBL Cisplatin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cisplatin

Indications/Uses

Monotherapy or combination therapy for palliative treatment of metastatic non-seminomatous germ cell carcinoma, advanced stage refractory ovarian & bladder carcinoma & refractory squamous cell head & neck carcinoma.

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Dosage/Direction for Use

Adult & childn 50-100 mg/m² as single IV infusion every 3-4 wk or 15-20 mg/m² daily as IV infusion for 5 days every 3-4 wk.

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Overdosage

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Contraindications

Hypersensitivity to cisplatin- or platinum-containing compd. Hearing disorders, bone marrow depression. Renal impairment. Pregnancy & lactation.

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Special Precautions

Anaphylactic-like reactions, history of atopy. Myelosuppression; anaemia; nausea, vomiting; ototoxicity; hypomagnesaemia & hypocalcaemia; peripheral neuropathy, postural hypotension, myasthenic syndromes, seizures, loss of vision; CV toxicity. Ensure adequate hydration to minimise risk of nephrotoxicity. Monitor renal function including GFR, BUN, serum creatinine & CrCl prior to & during treatment. Perform peripheral blood counts, neurological exam & monitor electrolytes at regular intervals. Monitor liver function periodically. Hepatic & renal impairment, preexisting renal dysfunction. May affect male fertility. Women of childbearing potential should use effective contraception. Not recommended during pregnancy. Not to be used during lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Severe nausea & vomiting; renal & urinary disorders; mild bone marrow toxicity; nnaphylactic & anaphylactic-like reactions eg, flushing, facial oedema, wheezing, tachycardia, hypotension; tinnitus &/or hearing loss; autonomic neuropathy, seizures, slurred speech, loss of taste & memory, CVA; retinal & pulmonary toxicity; CV abnormalities; VTE; mild alopecia; myalgia; electrolyte disturbances; pyrexia, local effects eg, phlebitis, cellulitis, skin necrosis.

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Drug Interactions

Exacerbated nephrotoxic & ototoxic effects w/ aminoglycosides & loop diuretics. Not to be used w/ live virus vaccines. Black precipitate formation w/ Al.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view DBL Cisplatin detailed prescribing information

Storage

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Description

View DBL Cisplatin description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01XA01 - cisplatin ; Belongs to the class of platinum-containing antineoplastic agents. Used in the treatment of cancer.

Regulatory Classification

Presentation/Packing

Form

DBL Cisplatin inj 1 mg/mL

Packing/Price

50 mL x 1's

DBL Cisplatin

cisplatin

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma