Adult Bladder cancer Combination therapy: 1,000 mg/m
2 given as 30-min IV infusion on days 1, 8 & 15 of each 28-day cycle in combination w/ cisplatin 70 mg/m
2 on day 1 or 2 of each 28-day cycle.
Pancreatic cancer 1,000 mg/m
2 given as 30-min IV infusion. Repeated once wkly for up to 7 wk, followed by 1-wk rest period.
NSCLC
Monotherapy: 1,000 mg/m
2 given as 30-min IV infusion. Repeated once wkly for 3 wk, followed by 1-wk rest period. This 4-wk cycle is then repeated. Combination therapy: 1,250 mg/m
2 given as 30-min IV infusion on days 1 & 8 of each 21-day cycle in combination w/ cisplatin 75-100 mg/m
2 once every 3 wk.
Ovarian cancer Combination therapy: 1,000 mg/m
2 given as 30 min IV infusion on days 1 & 8 of each 21-day cycle followed by carboplatin on day 1 to attain target AUC of 4 mg/mL/min.
Breast cancer Combination therapy: Paclitaxel 175 mg/m
2 given as 3-hr IV infusion on day 1, followed by gemcitabine 1,250 mg/m
2 given as 30-min IV infusion on days 1 & 8 of each 21-day cycle.