DBL Leucovorin Ca

DBL Leucovorin Ca

calcium folinate

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Leucovorin Ca
Indications/Uses
Certain megaloblastic anaemia resulting from folic acid deficiency in infant, during pregnancy, in malabsorption syndromes, liver diseases, sprue & malnutrition. Reducing toxicity & circumventing effect of folic acid antagonists.
Dosage/Direction for Use
Leucovorin rescue after methotrexate therapy 15 mg every 6 hr for 10 doses 24 hr after start of methotrexate infusion. Normal methotrexate elimination 15 mg orally, IM or IV every 6 hr for 60 hr (10 doses starting at 24 hr after start of methotrexate infusion). Delayed methotrexate elimination Continue 15 mg orally, IM or IV every 6 hr until methotrexate level is <0.05 micromolar. Impaired methotrexate elimination or inadvertent overdosage 10 mg/m2 IV, IM or orally every 6 hr, may be increased to 100 mg/m2 IV every 3 hr until serum methotrexate level is <10-8 M. Megaloblastic anaemia Up to 1 mg daily. Pyrimethamine overdosage 3-9 mg daily IM for 3 days or until platelet & leucocyte counts reached safety.
Contraindications
Pernicious anemia or other megaloblastic anemia secondary to vit B12 deficiency.
Special Precautions
Patients w/ CNS metastases. Concomitant use w/ fluorouracil, fluoropyrimidine. Not recommended w/ concomitant folic acid antagonist. Lactation. Elderly.
Adverse Reactions
Allergic sensitisation; nausea & vomiting (high doses).
Drug Interactions
Counteracted phenobarb, phenytoin, primidone antiepileptic effect in large doses. Reduced efficacy of intrathecal methotrexate. Enhanced fluorouracil toxicity. Incompatible w/ droperidol & phosphonosulphate.
MIMS Class
Antidotes & Detoxifying Agents / Supportive Care Therapy
ATC Classification
V03AF03 - calcium folinate ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
Presentation/Packing
Form
DBL Leucovorin Ca inj 50 mg/5 mL
Packing/Price
1's
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