DBL Leucovorin Ca

DBL Leucovorin Ca

calcium folinate




Zuellig Pharma


Concise Prescribing Info
Leucovorin Ca
Certain megaloblastic anaemia resulting from folic acid deficiency in infant, during pregnancy, in malabsorption syndromes, liver diseases, sprue & malnutrition. Reducing toxicity & circumventing effect of folic acid antagonists.
Dosage/Direction for Use
Leucovorin rescue after methotrexate therapy 15 mg every 6 hr for 10 doses 24 hr after start of methotrexate infusion. Normal methotrexate elimination 15 mg orally, IM or IV every 6 hr for 60 hr (10 doses starting at 24 hr after start of methotrexate infusion). Delayed methotrexate elimination Continue 15 mg orally, IM or IV every 6 hr until methotrexate level is <0.05 micromolar. Impaired methotrexate elimination or inadvertent overdosage 10 mg/m2 IV, IM or orally every 6 hr, may be increased to 100 mg/m2 IV every 3 hr until serum methotrexate level is <10-8 M. Megaloblastic anaemia Up to 1 mg daily. Pyrimethamine overdosage 3-9 mg daily IM for 3 days or until platelet & leucocyte counts reached safety.
Pernicious anemia or other megaloblastic anemia secondary to vit B12 deficiency.
Special Precautions
Patients w/ CNS metastases. Concomitant use w/ fluorouracil, fluoropyrimidine. Not recommended w/ concomitant folic acid antagonist. Lactation. Elderly.
Adverse Reactions
Allergic sensitisation; nausea & vomiting (high doses).
Drug Interactions
Counteracted phenobarb, phenytoin, primidone antiepileptic effect in large doses. Reduced efficacy of intrathecal methotrexate. Enhanced fluorouracil toxicity. Incompatible w/ droperidol & phosphonosulphate.
MIMS Class
Antidotes & Detoxifying Agents / Supportive Care Therapy
ATC Classification
V03AF03 - calcium folinate ; Belongs to the class of detoxifying agents used in antineoplastic treatment.
DBL Leucovorin Ca inj 50 mg/5 mL
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