Trophoblastic neoplasm 15-30 mg PO or IM for 5 days. Repeat course may be given after ≥1 wk. Normally, 3-5 courses are employed.
Breast carcinoma 40 mg/m
2 IV on 1st & 8th days.
Induction of lymphoblastic leukaemia remission 3.3 mg/m
2 orally w/ prednisolone 60 mg/m
2 daily. Maintenance: 30 mg/m
2 orally or IM twice wkly
or 2.5 mg/kg IV every 14 days.
Meningeal leukaemia ≥3 yr 12 mg,
2 yr 10 mg,
1 yr 8 mg,
<1 yr 6 mg administered by intrathecal inj & repeated at intervals of 2-5 days.
Stage I/II Burkitt's lymphoma 10-25 mg daily PO for 4-8 days.
Stage III lymphosarcoma 0.625-2.5 mg/kg daily.
Mycosis fungoides 2.5-10 mg daily PO for wk/mth or 50 mg IM once wkly or 25 mg IM twice wkly.
Psoriasis chemotherapy Wkly single dose schedule: 10-25 mg PO, IM/IV wkly. Max: 50 mg/wk. Divided dose schedule: 2.5 mg PO at 12-hr intervals for 3 doses or at 8-hr intervals for 4 doses wkly. Max: 30 mg/wk. Daily dose schedule: 2.5 mg PO daily for 5 days followed by rest period of at least 2 days. Max: 6.25 mg daily.
RA chemotherapy Initially 7.5 mg once wkly or 2.5 mg PO in divided doses at 12-hr intervals for 3 doses as once wkly course. Dosage in each schedule may be increased to 15 mg/wk after 6 wk. Max: 20 mg/wk.
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