DBL Pentamidine Isethionate

DBL Pentamidine Isethionate

pentamidine isetionate

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma

Marketer:

DKSH
Concise Prescribing Info
Contents
Pentamidine isethionate
Indications/Uses
Alternative 1st-line treatment of Pneumocystis carinii infection in AIDS patients & Leishmania aethiopica; 2nd-line treatment of Pneumocystis carinii infection in non-AIDS patients, Leishmaniasis (visceral & cutaneous) & Trypanosomiasis (except for Trypanosomiasis rhodesiense).
Dosage/Direction for Use
Pseudomonas carinii pneumonia 4 mg/kg once daily by slow IV infusion for 14 days. Leishmaniasis Visceral: 3-4 mg/kg on alternate days to a max of 10 inj. Cutaneous: 3-4 mg/kg once or twice wkly until condition resolves. Trypanosomiasis 4 mg/kg daily or on alternate days to a total of 7-10 inj.
Contraindications
Special Precautions
Pancreatitis, cardiac arrhythmias, hypocalcaemia, ventricular tachycardia. Malnutrition, hyper-/hypoglycaemia, HTN/hypotension, anaemia, leucopenia or thrombocytopenia. Monitor BUN, serum creatinine, Ca & electrolytes, complete blood & platelet counts, fasting blood glucose, liver function tests, urine analysis & ECG before, during & after treatment. Hepatic & renal dysfunction. Childn. Elderly.
Adverse Reactions
Severe hypotension & hypoglycaemia; acute pancreatitis; cardiac arrhythmias & arrest; syncope; ventricular tachycardia; leucopenia, thrombocytopenia; acute renal failure; hypocalcaemia; Stevens-Johnson syndrome; toxic delirium; Herxheimer reaction. Azotaemia, increased creatinine levels, albuminuria; anaemia; hyperkalaemia, hyponatraemia; nausea & vomiting; hyperglycaemia; dizziness; flushing; rash; taste disturbance; local reactions at inj site; bradycardia; breathlessness.
Drug Interactions
Additive nephrotoxic effects w/ other nephrotoxic drugs.
ATC Classification
P01CX01 - pentamidine isethionate ; Belongs to the class of other agents used in the treatment of leishmaniasis and trypanosomiasis.
Presentation/Packing
Form
DBL Pentamidine Isethionate powd for inj 4 mg/mL
Packing/Price
75 mL x 1's
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