Deflazacort


Concise Prescribing Info
Indications/Uses
Allergic and inflammatory disorders.
Dosage/Direction for Use
Adult : PO Initial: Up to 120 mg/day. Maintenance: 3-18 mg/day.
Dosage Details
Oral
Allergic and inflammatory disorders
Adult: Initially, up to 120 mg daily. Maintenance: 3-18 mg daily.
Child: 0.25-1.5 mg/kg daily or on alternate days.
Contraindications
Systemic infection (unless specific therapy is given). Concurrent admin of live virus vaccines in patients receiving immunosuppressive doses.
Special Precautions
Patient w/ infection, history of TB, cardiac disease or CHF (except in the presence of active rheumatic carditis), HTN, thromboembolic disorders, GI disorders (i.e. gastritis, diverticulitis, ulcerative colitis, peptic ulcer, pyogenic infections), DM (including family history), osteoporosis, myasthenia gravis, epilepsy, emotional instability, history of corticosteroid-induced myopathy, hypothyroidism, ocular herpes simplex. Avoid abrupt withdrawal after prolonged therapy. Renal and hepatic (including hepatic failure and cirrhosis) impairment. Childn. Pregnancy and lactation.
Adverse Reactions
Wt gain, hypothalamic-pituitary-adrenal (HPA) axis suppression, amenorrhoea, Cushingoid facies, growth suppression (childn), increased appetite, opportunistic infections, candidiasis, osteoporosis, myopathy, menstrual irregularity, heart failure, headache, vertigo, restlessness, depression, labile mood, irritability, euphoria, mania, delusions, hallucinations, schizophrenia, behavioural disturbances, anxiety, sleep disturbances, cognitive dysfunction including confusion and amnesia, increased intra-ocular pressure, glaucoma, chorioretinopathy, corneal/scleral thinning, posterior subcapsular cataract, dyspepsia, peptic ulceration, haemorrhage, nausea, acute pancreatitis (childn), hirsutism, striae, acne, skin atrophy, telangiectasia, oedema, impaired healing, leukocytosis. Rarely, muscle wasting, bruising, benign intracranial HTN.
MonitoringParameters
Monitor growth, height and wt esp in childn.
Drug Interactions
Decreased serum concentration when used w/ hepatic enzyme inducers (e.g. rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone, aminoglutethimide). Increased serum concentration if concurrently used w/ hepatic enzyme inhibitors (e.g. ketoconazole). Antagonises the effect of hypoglycaemic agents, antihypertensives and diuretics. Enhances the hypokalaemic effect of acetazolamide, loop/thiazide diuretics, β2-agonists, xanthines and carbenoxolone. May increase the anticoagulant effect of coumarins. May prolong relaxation and acute myopathy when given w/ non-depolarising muscle relaxants. Increases the renal clearance of salicylates, steroid withdrawal may lead to salicylate intoxication. Increased serum concentrations w/ oral contraceptives. Reduced bioavailability w/ antacids. Increased risk of tendonitis and tendon rupture if concomitantly used w/ quinolones.
Lab Interference
May suppress reaction to skin tests.
Action
Description: Deflazacort is a glucocorticoid derived from prednisolone. It acts as anti-inflammatory and immunosuppressive agent.
Pharmacokinetics:
Absorption: Well absorbed from the GI tract. Time to peak plasma concentration: 1.5-2 hr.
Distribution: Plasma protein binding: 40%.
Metabolism: Immediately converted to the active metabolite, D 21-OH, by plasma esterases.
Excretion: Via urine (70%) and faeces (30%). Elimination half-life: 1.1-1.9 hr.
Storage
Store at or below 25°C.
ATC Classification
H02AB13 - deflazacort ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
Disclaimer: This information is independently developed by MIMS based on Deflazacort from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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