Demoxytocin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Buccal Labour induction 50 u every 30 mins, reduce to 25 u every 30 mins when normal contraction rhythm achieved. Max: 500 units. Labour augmentation 25 or 50 u every 30 mins if needed.
Dosage Details
Buccal
Labour induction
Adult: 50 units every 30 minutes, reduce to 25 units every 30 minutes when normal contraction rhythm is established. Max: 500 units.

Buccal
Labour augmentation
Adult: 25 or 50 units if necessary every ½ hr.
Contraindications
Foetal distress, significant cephalopelvic disproportion, unfavorable presentation of the fetus, excess uterine distention; parity >4; elderly multiparae; previous uterine surgery; severe toxemia; amniotic fluid embolism; hypertonic uterine contractions; placenta praevia; cord presentation or prolapse; mechanical obstruction to delivery; predisposition to uterine rupture.
Special Precautions
Borderline cephalopelvic disproportion; patients >35 yr. Monitor fetal heart rate and uterine motility. Do not employ for prolonged periods in resistant uterine inertia, severe preeclampsia, severe CV disorders. Discontinue in case of foetal distress or uterine hyperactivity. Risk of water intoxication (high doses over prolonged period). Restrict fluid intake by mouth.
Adverse Reactions
Postpartum bleeding; neonatal jaundice; water retention; acute transient hypotension with flushing and reflex tachycardia (rapid IV).
Potentially Fatal: Death; anaphylactic reactions; fatal afibrinogenaemia; maternal deaths from severe hypertension and subarachnoid haemorrhage.
Drug Interactions
Prostaglandins, anaesthetics. Vasopressor effects of sympathomimetics may be enhanced.
Action
Description: Demoxytocin is a synthetic analogue of oxytocin that causes uterine contraction. It is used for induction and augmentation of labour.
Disclaimer: This information is independently developed by MIMS based on Demoxytocin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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