Denzol Mechanism of Action





Averroes Pharma
Full Prescribing Info
Pharmacology: Pharmacodynamics: Albendazole is a broad spectrum anthelmintic with activity against most nematodes and some cestodes. Albendazole acts by destruction of cytoplasmic microtubules in the worm's intestinal or absorptive cells and inhibition of glucose uptake and other nutrients in susceptible helminths, resulting in death of the worm.
Pharmacokinetics: Albendazole is poorly absorbed from GI tract, and is rapidly metabolized in the liver to the active albendazole sulphoxide, which is approximately 70% bound to the plasma protein. Peak plasma concentrations occur in 2-5 hours after dosing. It has a plasma half-life of about 8.5 hours and is primarily eliminated in the bile.
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