Some animal studies have shown that corticosteroids when administered to the mother at high doses may cause fetal malformations. Since adequate human reproduction studies have not been done with glucocorticoids, the use of these drugs in pregnancy, nursing mothers or women of childbearing potential, requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus. Glucocorticoids should be used during pregnancy only if clearly needed. If a chronic treatment with corticosteroids has to be stopped during pregnancy (as with other chronic treatments), this should occur gradually (see also DOSAGE & ADMINISTRATION). In some cases (e.g. substitution treatment of adrenocortical insufficiency) however, it can be necessary to continue treatment or even to increase dosage. Corticosteroids readily cross the placenta. New-born infants born of mothers who have received substantial doses of glucocorticosteroids during pregnancy, should be carefully observed and evaluated for signs of adrenal insufficiency.
In case of labor and delivery no effects are known.
Corticosteroids are excreted in breast milk.