Patients w/ significant bladder outlet obstruction at risk of urinary retention; GI obstructive disorders eg, pyloric stenosis; autonomic neuropathy; hiatus hernia; decreased GI motility. Congenital or documented acquired QT prolongation, electrolyte disturbances eg, hypokalaemia, hypomagnesaemia, hypocalcaemia; bradycardia, relevant preexisting cardiac diseases eg, cardiomyopathy, MI, arrhythmia, CHF. Avoid concomitant use w/ potent CYP3A4 inhibitors. Concomitant use w/ drugs prolonging QT interval including class IA & III antiarrhythmics. May affect ability to drive & use machines. Renal impairment, hepatic disease. Not recommended during pregnancy. Avoid use during lactation. Childn.