Zuellig Pharma
Concise Prescribing Info
Tolterodine tartrate
Overactive bladder w/ symptoms of urinary urgency, frequency or urge incontinence.
Dosage/Direction for Use
Adult including elderly 2 mg bd, may be reduced to 2 mg once daily based on individual tolerability. Total daily dose: 4 mg. Patient receiving potent CYP3A4 inhibitors, renal & hepatic impairment 1 mg bd. Total daily dose: 2 mg.
May be taken with or without food.
Hypersensitivity. Urinary retention, uncontrolled narrow angle glaucoma, myasthenia gravis, severe ulcerative colitis, toxic megacolon.
Special Precautions
Patients w/ significant bladder outlet obstruction at risk of urinary retention; GI obstructive disorders eg, pyloric stenosis; autonomic neuropathy; hiatus hernia; decreased GI motility. Congenital or documented acquired QT prolongation, electrolyte disturbances eg, hypokalaemia, hypomagnesaemia, hypocalcaemia; bradycardia, relevant preexisting cardiac diseases eg, cardiomyopathy, MI, arrhythmia, CHF. Avoid concomitant use w/ potent CYP3A4 inhibitors. Concomitant use w/ drugs prolonging QT interval including class IA & III antiarrhythmics. May affect ability to drive & use machines. Renal impairment, hepatic disease. Not recommended during pregnancy. Avoid use during lactation. Childn.
Adverse Reactions
Headache; dry mouth. Bronchitis; dizziness, somnolence, paresthesia; dry eyes, abnormal vision including abnormal accommodation; vertigo; palpitations; dyspepsia, constipation, abdominal pain, flatulence, vomiting, diarrhea; dry skin; dysuria, urinary retention; fatigue, chest pain, peripheral oedema; increased wt.
Drug Interactions
Increased serum conc w/ potent CYP3A4 inhibitors eg, macrolide antibiotics, antifungals, antiproteases. Reduced therapeutic effect w/ muscarinic cholinergic receptor agonists. Decreased effect of prokinetics eg, metoclopramide, cisapride.
ATC Classification
G04BD07 - tolterodine ; Belongs to the class of urinary antispasmodics.
Detrusitol FC tab 2 mg
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