Dexamethasone + Neomycin + Polymyxin B


Concise Prescribing Info
Indications/Uses
Ocular inflammation with suspected or confirmed bacterial infection.
Dosage/Direction for Use
Adult : Ophth Per g oint or per mL susp contains dexamethasone 0.1%, neomycin sulfate equiv to neomycin 3.5 mg and polymyxin B sulfate 10,000 u. For ointment: Apply 3-4 times/day. For susp: Instill 4-6 times/day, up to hrly in severe disease.
Dosage Details
Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: Each g of ophthalmic ointment contains dexamethasone 0.1%, neomycin sulfate equivalent to neomycin 3.5 mg and polymyxin B sulfate 10,000 units. Apply a small amount into the conjunctival sac(s) of the affected eye(s) up to 3-4 times daily. Each ml of ophthalmic liquid contains dexamethasone 0.1%, neomycin sulfate equivalent to neomycin 3.5 mg and polymyxin B sulfate 10,000 units. Instill 1-2 drops in the conjunctival sac(s) of the affected eye(s) up to 4-6 times daily; may be used up to hrly in severe disease. Reduce frequency once condition improves.
Contraindications
Hypersensitivity. Epithelial herpes simplex keratitis (dendritic keratitis), varicella and viral diseases of the cornea and conjunctiva. Mycobacterial infection or fungal diseases of the eye. Amoeba infections or untreated purulent infections of the eye.
Special Precautions
Prolonged use may cause glaucoma, damage to the optic nerve, defects in visual acuity and fields of vision, posterior subcapsular cataract formation and increased risk of secondary ocular infections. Increased risk of perforations in diseases which can cause thinning of the cornea or sclera. Corticosteroids may mask infection or worsen existing infections in acute purulent conditions of the eye. Regular monitoring of the intraocular pressure is recommended if product is used for ≥10 days. Long term application of topical corticosteroids may also increase the risk of ocular fungal infections. Neomycin sulfate may cause cutaneous sensitisation. Pregnancy and lactation.
Adverse Reactions
Allergic sensitisations. Increased intraocular pressure and delayed wound healing. Irritation, burning, stinging, itching and dermatitis.
Overdosage
Prolonged excessive use may lead to systemic effects.
Action
Description: Dexamethasone is a corticosteroid with mainly glucocorticoid activity; it is used topically mainly for its anti-inflammatory action. Neomycin is a broad-spectrum aminoglycoside antibiotic that is used topically for the treatment of infections of the skin, ear and eye due to susceptible staphylococci and other organisms. Polymyxin B is active only against gram-negative bacteria especially Pseudomonas aeruginosa.
Pharmacokinetics:
Absorption: Dexamethasone/neomycin/polymyxin B: Sufficiently absorbed after ophthalmic application to exert pharmacological effects.
Storage
Store at 2-25°C. Stable for 28 days after opening.
Disclaimer: This information is independently developed by MIMS based on Dexamethasone + Neomycin + Polymyxin B from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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